BROWSE

Related Researcher

Author

Hong, Sung You
Synthetic Organic Chemistry Laboratory
Research Interests
  • Synthetic organic chemistry, transition metals, oxidation state

ITEM VIEW & DOWNLOAD

Ferritin protein cage nanoparticles as versatile antigen delivery nanoplatforms for dendritic cell (DC)-based vaccine development

Cited 0 times inthomson ciCited 0 times inthomson ci
Title
Ferritin protein cage nanoparticles as versatile antigen delivery nanoplatforms for dendritic cell (DC)-based vaccine development
Author
Han, Jae-AKang, Young JiShin, ChangsikRa, Jae-SunShin, Hyun-HeeHong, Sung YouDo, YoonkyungKang, Sebyung
Keywords
Antigen delivery; Dendritic cells; Ferritin; Protein cage; Vaccine
Issue Date
201404
Publisher
ELSEVIER SCIENCE BV
Citation
NANOMEDICINE-NANOTECHNOLOGY BIOLOGY AND MEDICINE, v.10, no.3, pp.561 - 569
Abstract
We utilized ferritin protein cage nanoparticles (FPCN) as antigen delivery nanoplatforms for DC-based vaccine development and investigated DC-mediated antigen-specific immune responses. Antigenic peptides, OT-1 (SIINFEKL) or OT-2 (ISQAVHAAHAEINEAGR) which are derived from ovalbumin, were genetically introduced either onto the exterior surface or into the interior cavity of FPCN. FPCN carrying antigenic peptides (OT-1-FPCN and OT-2-FPCN) were effectively delivered to DCs and processed within endosomes. Delivered antigenic peptides, OT-1 or OT-2, to DCs successfully induced antigen-specific CD8+ or CD4+ T cell proliferations both in vitro and in vivo. Naïve mice immunized with OT-1-FPCN efficiently differentiated OT-1 specific CD8+ T cells into functional effector cytotoxic T cells resulting in selective killing of antigen-specific target cells. Effective differentiation of proliferated OT-2 specific CD4+ T cells into functional CD4+ Th1 and Th2 cells was confirmed with the productions of IFN-γ/IL-2 and IL-10/IL-13 cytokines, respectively.
URI
Go to Link
DOI
http://dx.doi.org/10.1016/j.nano.2013.11.003
ISSN
1549-9634
Appears in Collections:
SLS_Journal Papers
ECHE_Journal Papers

find_unist can give you direct access to the published full text of this article. (UNISTARs only)

Show full item record

qr_code

  • mendeley

    citeulike

Items in DSpace are protected by copyright, with all rights reserved, unless otherwise indicated.

MENU