(R)-Lipo-Diaza-18-Crown-6 Self-Assembled Monolayer as a Selective Serotonin Receptor
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- (R)-Lipo-Diaza-18-Crown-6 Self-Assembled Monolayer as a Selective Serotonin Receptor
- Park, Jin-Young; Lee, Yoon-Suk; Chang, Byoung-Yong; Karthikeyan, S.; Kim, Kwang S.; Kim, Byeang Hyean; Park, Su-Moon
- 18-crown-6; Ammonium ions; Ascorbic acids; Charge transfer resistance; Driving forces; Electrochemical experiments; Electrostatic attractions; Inclusion complex; Interferents; Molecular modeling studies; Redox probe; Selective receptors; Serotonin receptors
- Issue Date
- AMER CHEMICAL SOC
- ANALYTICAL CHEMISTRY, v.81, no.10, pp.3843 - 3850
- A highly selective receptor for serotonin was designed using cages formed by the (R)-lipo-diaza-18-crown-6 self-assembled monolayer (SAM) on gold and experimentally verified by a variety of electrochemical experiments in solutions containing large amounts of dopamine and ascorbic acid, as well as other interferents. The molecular modeling study showed that parameters such as the H-pi interaction provided important driving forces for the cage to form a strong inclusion complex with serotonin. The charge-transfer resistance (R(CT)'s) to/from redox probe ions, Fe(CN)(6)(3-5-), was greatly enhanced because of their electrostatic attractions to ammonium ions of serotonin molecules captured by cages. The changes in R(CT)-values were shown to be remarkably selective for serotonin in the presence of many interferents.
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