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Madou, Mark
BIO-MEMS Lab
Research Interests
  • Medical Diagnostics

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Large-volume centrifugal microfluidic device for blood plasma separation

Cited 22 times inthomson ciCited 24 times inthomson ci
Title
Large-volume centrifugal microfluidic device for blood plasma separation
Author
Amasia, MaryMadou, Marc
Keywords
ON-A-CHIP; WHOLE-BLOOD; LAB; DISK; EXTRACTION; PLATFORM; SYSTEMS
Issue Date
201010
Publisher
FUTURE SCI LTD
Citation
BIOANALYSIS, v.2, no.10, pp.1701 - 1710
Abstract
Background: Microfluidic-based systems are ideal for handling small microliter volumes of samples and reagents, but 'real-world' or clinical samples for bioanalysis are often on the milliliter scale. We aimed to develop and validate a large-volume centrifugal or compact disc-based device for blood plasma separation, capable of processing 2 ml undiluted blood samples. Results: This automated blood sample preparation device was shown to yield high purity plasma in less than half the time of commercial plasma preparation tubes, while enabling integration with downstream analysis and detection steps. Conclusion: This article draws upon a novel large-volume device to further illustrate the challenges in combining microfluidics structures with large-volume samples and the implications for sample-driven microfluidics systems.
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DOI
http://dx.doi.org/10.4155/BIO.10.140
ISSN
1757-6180
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SLS_Journal Papers
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