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Suh, Pann-Ghill
BioSignal Network Lab (BSN)
Research Interests
  • Signal transduction, cancer, metabolism, phospholipase C

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Secretomics for skeletal muscle cells: A discovery of novel regulators?

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Title
Secretomics for skeletal muscle cells: A discovery of novel regulators?
Author
Yoon, Jong HyukKim, JaeyoonSong, ParkyongLee, Taehoon G.Suh, Pann-GhillRyu, Sung Ho
Issue Date
201205
Publisher
ELSEVIER
Citation
ADVANCES IN BIOLOGICAL REGULATION, v.52, no.2, pp.340 - 350
Abstract
Metabolic tissues, including skeletal muscle, adipose tissue and the digestive system, dynamically secrete various factors depending on the metabolic state, communicate with each other and orchestrate functions to maintain body homeostasis. Skeletal muscle secretes cytokines such as interleukin-6 (IL-6), IL-15, fibroblast growth factor-21 (FGF21) and IL-8. These compounds, myokines, play important roles in biological homeostasis such as energy metabolism, angiogenesis and myogenesis. New technological advances have allowed secretomics – analysis of the secretome – to be performed. The application of highly sensitive mass spectrometry makes qualitative and quantitative analysis of the secretome of skeletal muscle possible. Secretory proteins derived from skeletal muscle cells under various conditions were analyzed, and many important factors were suggested. In-depth studies of the secretome from metabolic cells in various conditions are strongly recommended. This study will provide information on methods of novel communication between metabolic tissues.
URI
http://scholarworks.unist.ac.kr/handle/201301/3813
DOI
http://dx.doi.org/10.1016/j.jbior.2012.03.001
ISSN
2212-4926
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