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DC Field | Value | Language |
---|---|---|
dc.citation.endPage | 4033 | - |
dc.citation.number | 9 | - |
dc.citation.startPage | 4030 | - |
dc.citation.title | JOURNAL OF THE AMERICAN CHEMICAL SOCIETY | - |
dc.citation.volume | 134 | - |
dc.contributor.author | Kim, Hyunkyu | - |
dc.contributor.author | Kang, Young Ji | - |
dc.contributor.author | Kang, Sebyung | - |
dc.contributor.author | Kim, Kyoung Taek | - |
dc.date.accessioned | 2023-12-22T05:17:05Z | - |
dc.date.available | 2023-12-22T05:17:05Z | - |
dc.date.created | 2013-06-13 | - |
dc.date.issued | 2012-03 | - |
dc.description.abstract | We synthesized a boroxole-containing styrenic monomer that can be polymerized by the reversible addition fragmentation and chain transfer (RAFT) method. Poly(styreneboroxole) (PBOx) and its block copolymers with a poly(ethylene glycol) (PEG) as a hydrophilic block displayed binding to monosaccharides in phosphate buffer at neutral pH, as quantified by Wang's competitive binding experiments. By virtue of a controlled radical polymerization, we were able to adjust the degree of polymerization of the PBOx block to yield sugar-responsive block copolymers that self-assembled into a variety of nanostructures including spherical and cylindrical micelles and polymer vesicles (polymersomes). Polymersomes of these block copolymers exhibited monosaccharide-responsive disassembly in a neutral-pH medium. We demonstrated the possibility of using these polymersomes as sugar-responsive delivery vehicles for insulin in neutral phosphate buffer (pH 7.4). Encapsulated insulin could be released from the polymersomes only in the presence of sugars under physiologically relevant pH conditions. | - |
dc.identifier.bibliographicCitation | JOURNAL OF THE AMERICAN CHEMICAL SOCIETY, v.134, no.9, pp.4030 - 4033 | - |
dc.identifier.doi | 10.1021/ja211728x | - |
dc.identifier.issn | 0002-7863 | - |
dc.identifier.scopusid | 2-s2.0-84863234538 | - |
dc.identifier.uri | https://scholarworks.unist.ac.kr/handle/201301/3811 | - |
dc.identifier.url | http://www.scopus.com/inward/record.url?partnerID=HzOxMe3b&scp=84863234538 | - |
dc.identifier.wosid | 000301550800026 | - |
dc.language | 영어 | - |
dc.publisher | AMER CHEMICAL SOC | - |
dc.title | Monosaccharide-Responsive Release of Insulin from Polymersomes of Polyboroxole Block Copolymers at Neutral pH | - |
dc.type | Article | - |
dc.relation.journalWebOfScienceCategory | Chemistry, Multidisciplinary | - |
dc.relation.journalResearchArea | Chemistry | - |
dc.description.journalRegisteredClass | scie | - |
dc.description.journalRegisteredClass | scopus | - |
dc.subject.keywordPlus | BORONIC ACID | - |
dc.subject.keywordPlus | PHYSIOLOGICAL PH | - |
dc.subject.keywordPlus | VESICLES | - |
dc.subject.keywordPlus | BINDING | - |
dc.subject.keywordPlus | RECEPTOR | - |
dc.subject.keywordPlus | WATER | - |
dc.subject.keywordPlus | COMPLEXATION | - |
dc.subject.keywordPlus | RECOGNITION | - |
dc.subject.keywordPlus | MONOMERS | - |
dc.subject.keywordPlus | DESIGN | - |
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