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Kwak, Sang Kyu
Kyu’s MolSim Lab @ UNIST
Research Interests
  • Molecular modeling and simulation, statistical thermodynamics, molecular physics

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Estimation of optimal insertion angle in a mammalian outer hair cell stereocilium

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Title
Estimation of optimal insertion angle in a mammalian outer hair cell stereocilium
Author
Baek, Jong DaeYoon, Yong-JinAbedinnasab, Mohammad H.Han, BeibeiKwak, Sang Kyu
Keywords
Finite element model; Mechanical Deflection; Outer Hair Cell (OHC); Stereocilia; Tectorial Membrane (TM)
Issue Date
201206
Publisher
ELSEVIER SCI LTD
Citation
JOURNAL OF BIOMECHANICS, v.45, no.10, pp.1823 - 1827
Abstract
Optimal insertion angle of mammalian stereocilia is estimated from the finite element analysis of the tip motion of outer hair cells (OHCs) stereocilia. The OHC stereocilia motion in the acousticolateral system appears to result in the mechanoelectrical transduction channels. Deflection of the hair bundle towards the tallest row of stereocilia causes increased probability of opening of ion channels. In this work, we focus on one of the physical features of the OHC stereocilium, the initial insertion angle of the tallest row into the tectorial membrane (TM), and its effects on the stereocilia's deflection motion. A three-dimensional model was built for the tallest stereocilium and the TM at the region where the best frequency was 500. Hz. The mechanical interactions between the embedded stereocilia and the TM have been implemented into the finite element simulation. We found that, the optimum insertion angle of the tallest stereocilium into the TM was 69.8°, where the stereocilium is maximally deflected. This quantity is consistent with the histological observation obtained from the literature.
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DOI
http://dx.doi.org/10.1016/j.jbiomech.2012.04.012
ISSN
0021-9290
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