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Author

Lee, Chang Young
Carbon Nanomaterials Lab
Research Interests
  • Carbon nanomaterials, gas sensors, neuroanalytical chemistry, biomimetic nanosystems

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Carbon Nanotube-Patterned Surface-Based Recognition of Carcinoembryonic Antigens in Tumor Cells for Cancer Diagnosis

Cited 1 times inthomson ciCited 1 times inthomson ci
Title
Carbon Nanotube-Patterned Surface-Based Recognition of Carcinoembryonic Antigens in Tumor Cells for Cancer Diagnosis
Author
Kwon, TaeyunPark, JinsungLee, GyudoNam, KihwanHuh, Yong-MinLee, Seong-WookYang, JaemoonLee, Chang YoungEom, Kilho
Keywords
Aptamers; Biochemical analysis; Cancer diagnosis; Carcinoembryonic antigen; Circulating tumor cells; Label-free detection; Low concentrations; Marker proteins
Issue Date
201304
Publisher
AMER CHEMICAL SOC
Citation
JOURNAL OF PHYSICAL CHEMISTRY LETTERS, v.4, no.7, pp.1126 - 1130
Abstract
It has been of high significance to devise a biochemical analytical tool kit enabling the detection of few circulating tumor cells (CTCs) for early diagnosis of cancer. Despite recent effort made to detect few CTCs, it is still challenging to sense such cells with their low concentration and/or the minute amount of marker proteins expressed on few CTCs. In this work, we report the label-free recognition of carcinoembryonic antigens (CEAs) expressed on few CTCs by using a carbon nanotube (CNT) sensor coupled with scanning probe microscopy imaging for cancer diagnosis. It is shown that a CNT-patterned surface is able to specifically capture the CEA molecules in the whole cell lysate of CTCs with their concentration even up to 10(-3) cells/mL. Our work sheds light on our bioassay based on a CNT-patterned surface for highly sensitive, label-free detection of marker proteins expressed on few tumor cells, which may open a new avenue in early diagnosis of cancer by providing a novel biochemical analysis tool kit.
URI
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DOI
http://dx.doi.org/10.1021/jz400087m
ISSN
1948-7185
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