There are no files associated with this item.
Full metadata record
DC Field | Value | Language |
---|---|---|
dc.citation.endPage | 165 | - |
dc.citation.number | 1 | - |
dc.citation.startPage | 155 | - |
dc.citation.title | DEVELOPMENTAL BIOLOGY | - |
dc.citation.volume | 363 | - |
dc.contributor.author | Chung, Mei-I | - |
dc.contributor.author | Peyrot, Sara M. | - |
dc.contributor.author | LeBoeuf, Sarah | - |
dc.contributor.author | Park, Tae Joo | - |
dc.contributor.author | McGary, Kriston L. | - |
dc.contributor.author | Marcotte, Edward M. | - |
dc.contributor.author | Wallingford, John B. | - |
dc.date.accessioned | 2023-12-22T05:16:46Z | - |
dc.date.available | 2023-12-22T05:16:46Z | - |
dc.date.created | 2013-07-22 | - |
dc.date.issued | 2012-03 | - |
dc.description.abstract | In Caenorhabditis elegans, the RFX (Daf19) transcription factor is a major regulator of ciliogenesis, controlling the expression of the many essential genes required for making cilia. In vertebrates, however, seven RFX genes have been identified. Bioinformatic analysis suggests that Rfx2 is among the closest homologues of Daf19. We therefore hypothesize that Rfx2 broadly controls ciliogenesis during vertebrate development. Indeed, here we show that Rfx2 in Xenopus is expressed preferentially in ciliated tissues, including neural tube, gastrocoel roof plate, epidermal multi-ciliated cells, otic vesicles, and kidneys. Knockdown of Rfx2 results in cilia-defective embryonic phenotypes and fewer or truncated cilia are observed in Rfx2 morphants. These results indicate that Rfx2 is broadly required for ciliogenesis in vertebrates. Furthermore, we show that Rfx2 is essential for expression of several ciliogenic genes, including TTC25, which we show here is required for ciliogenesis. HH signaling, and left-right patterning. | - |
dc.identifier.bibliographicCitation | DEVELOPMENTAL BIOLOGY, v.363, no.1, pp.155 - 165 | - |
dc.identifier.doi | 10.1016/j.ydbio.2011.12.029 | - |
dc.identifier.issn | 0012-1606 | - |
dc.identifier.scopusid | 2-s2.0-84857033077 | - |
dc.identifier.uri | https://scholarworks.unist.ac.kr/handle/201301/3703 | - |
dc.identifier.url | http://www.scopus.com/inward/record.url?partnerID=HzOxMe3b&scp=84857033077 | - |
dc.identifier.wosid | 000300857800015 | - |
dc.language | 영어 | - |
dc.publisher | ACADEMIC PRESS INC ELSEVIER SCIENCE | - |
dc.title | RFX2 is broadly required for ciliogenesis during vertebrate development | - |
dc.type | Article | - |
dc.description.journalRegisteredClass | scie | - |
dc.description.journalRegisteredClass | scopus | - |
dc.subject.keywordAuthor | Rfx | - |
dc.subject.keywordAuthor | Ciliogenesis | - |
dc.subject.keywordAuthor | Cilia | - |
dc.subject.keywordAuthor | Multi-ciliated cells | - |
dc.subject.keywordAuthor | Rfx2 | - |
dc.subject.keywordAuthor | TTC25 | - |
dc.subject.keywordPlus | HISTONE H1T GENE | - |
dc.subject.keywordPlus | TRANSCRIPTION FACTOR RFX3 | - |
dc.subject.keywordPlus | BARE LYMPHOCYTE SYNDROME | - |
dc.subject.keywordPlus | DNA-BINDING PROTEINS | - |
dc.subject.keywordPlus | LEFT-RIGHT ASYMMETRY | - |
dc.subject.keywordPlus | REGULATORY FACTOR | - |
dc.subject.keywordPlus | PRIMARY CILIUM | - |
dc.subject.keywordPlus | PRIMARY SPERMATOCYTES | - |
dc.subject.keywordPlus | CELLS ANTENNA | - |
dc.subject.keywordPlus | DISEASE | - |
Items in Repository are protected by copyright, with all rights reserved, unless otherwise indicated.
Tel : 052-217-1404 / Email : scholarworks@unist.ac.kr
Copyright (c) 2023 by UNIST LIBRARY. All rights reserved.
ScholarWorks@UNIST was established as an OAK Project for the National Library of Korea.