BROWSE

Related Researcher

Author

Madou, Mark
BIO-MEMS Lab
Research Interests
  • Medical Diagnostics

ITEM VIEW & DOWNLOAD

Visualization and measurement of capillary-driven blood flow using spectral domain optical coherence tomography

Cited 3 times inthomson ciCited 2 times inthomson ci
Title
Visualization and measurement of capillary-driven blood flow using spectral domain optical coherence tomography
Author
Cito, SalvatoreAhn, Yeh-ChanPallares, JordiDuarte, Rodrigo MartinezChen, ZhongpingMadou, MarcKatakis, Ioanis
Keywords
Biological fluids; Blood flow; Capillary-driven flow; Convective effects; Cross-sectional imaging; Diagnostic applications; Doppler optical coherence tomography; High resolution; Lateral Flow; Lucas-Washburn equation; Micro-fluidic devices; Non-newtonian; Non-Newtonian fluids; Power law fluid; Power law model; Spectral domain optical coherence tomographies; Spectral-domain; Working fluid
Issue Date
201209
Publisher
SPRINGER HEIDELBERG
Citation
MICROFLUIDICS AND NANOFLUIDICS, v.13, no.2, pp.227 - 237
Abstract
Capillary-driven flow (CD-flow) in microchannels plays an important role in many microfluidic devices. These devices, the most popular being those based in lateral flow, are becoming increasingly used in health care and diagnostic applications. CD-flow can passively pump biological fluids as blood, serum or plasma, in microchannels and it can enhance the wall mass transfer by exploiting the convective effects of the flow behind the meniscus. The flow behind the meniscus has not been experimentally identified up to now because of the lack of high-resolution, non-invasive, cross-sectional imaging means. In this study, spectral-domain Doppler optical coherence tomography is used to visualize and measure the flow behind the meniscus in CD-flows of water and blood. Microchannels of polydimethylsiloxane and glass with different cross-sections are considered. The predictions of the flow behind the meniscus of numerical simulations using the power-law model for non-Newtonian fluids are in reasonable agreement with the measurements using blood as working fluid. The extension of the Lucas-Washburn equation to non-Newtonian power-law fluids predicts well the velocity of the meniscus of the experiments using blood.
URI
Go to Link
DOI
http://dx.doi.org/10.1007/s10404-012-0950-6
ISSN
1613-4982
Appears in Collections:
SLS_Journal Papers

find_unist can give you direct access to the published full text of this article. (UNISTARs only)

Show full item record

qr_code

  • mendeley

    citeulike

Items in DSpace are protected by copyright, with all rights reserved, unless otherwise indicated.

MENU