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Author

Song, Hyun-Kon
eclat: ElectroChemistry Lab of Advanced Technology
Research Interests
  • Electrochemical analysis, electroactive materials, electrochemistry-based energy devices

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Quantitative Control of Neuron Adhesion at a Neural Interface Using a Conducting Polymer Composite with Low Electrical Impedance

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Title
Quantitative Control of Neuron Adhesion at a Neural Interface Using a Conducting Polymer Composite with Low Electrical Impedance
Author
Kim, Sung YeolKim, Kwang-MinHoffman-Kim, DianeSong, Hyun-KonPamore, G. Tayhas R.
Keywords
Carbodiimide chemistry; Cell response; Conducting polymer composites; Electrical impedance; Electrochemical impedance; Electrode coating; Electrode surfaces; Electrodeposited coatings; Functionalized; Neural interfaces; Number of layers; Poly(L-lysine); Surface concentration
Issue Date
201101
Publisher
AMER CHEMICAL SOC
Citation
ACS APPLIED MATERIALS & INTERFACES, v.3, no.1, pp.16 - 21
Abstract
Tailoring cell response on an electrode is essential in the application of neural interfaces. In this paper a method of controlling neuron adhesion on the surface of an electrode was demonstrated using conducting polymer composite as an electrode coating. The electrodeposited coating was functionalized further with biomolecules-of-interest (BOI) with their surface concentration controlled via repetition of carbodiimide chemistry. The result was an electrode surface that promoted localized adhesion of primary neurons the density of which could be controlled quantitatively via changes in the number of layers of BOI added. Important to neural interfaces, it was found that additional layers of BOI caused an insignificant increase in the electrical impedance, especially when compared to the large drop in impedance upon coating of the electrode with conducting polymer composite.
URI
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DOI
http://dx.doi.org/10.1021/am1008369
ISSN
1944-8244
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