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Ghim, Cheol-Min
Physical Biology & Biological Physics
Research Interests
  • Control of complex networks, stochastic cell biology, biochemical information processing, human microbiome, ecological inference

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Engineering microorganisms for biofuel production

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Title
Engineering microorganisms for biofuel production
Author
Parisutham, VinuselviPark, Jung MinLee, Jae MyungOh, KikwangGhim, Cheol-MinLee, Sung Kuk
Keywords
Biofuel production; Catabolite repression; Cellulosic biomass; Chain alcohol; End-products; Expression system; Fatty acid methyl ester; Genetically modified; Genome engineering; Isoprenoids; Metabolic engineering; Metabolic pathways; Recombinant hosts; Synthetic biology
Issue Date
201103
Publisher
FUTURE SCIENCE LTD
Citation
BIOFUELS, v.2, no.2, pp.153 - 166
Abstract
The current challenges faced in the development of advanced biofuels from cellulosic biomass include the inefficiency of the recombinant hosts to hydrolyze lignocellulose, incomplete utilization of multiple sugars due to the presence of carbon-catabolite repression, lack of suitable gene-expression systems for coordinating multiple-gene expression, difficulties in optimizing a synthetic metabolic pathway and toxicity of both the substrate (lignin) and the end product (biofuel) to the recombinant host. Despite the aforementioned hurdles, potential biofuels such as short- or long-chain alcohols, alkanes, fatty acid methyl esters and isoprenoid-based fuels have been produced by metabolically engineered hosts, but with no promising improvement in the yield. An economically feasible advanced biofuel could be possible with the recent advances in metabolic engineering, genome engineering and synthetic biology through a genetically modified microbe or a synthetic microbe with a well-defined metabolism.
URI
http://scholarworks.unist.ac.kr/handle/201301/3616
DOI
http://dx.doi.org/10.4155/bfs.11.4
ISSN
1759-7269
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