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Park, Jongnam
Materials and Chemistry Lab (MCL)
Research Interests
  • Inorganic synthesis, microfluidics, nanomaterials, surface engineering, bioimaging

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Facile Synthetic Route for Surface-Functionalized Magnetic Nanoparticles: Cell Labeling and Magnetic Resonance Imaging Studies

Cited 0 times inthomson ciCited 32 times inthomson ci
Title
Facile Synthetic Route for Surface-Functionalized Magnetic Nanoparticles: Cell Labeling and Magnetic Resonance Imaging Studies
Author
Chung, Hyun JungLee, HaeshinBae, Ki HyunLee, YuhanPark, JongnamCho, Seung-WooHwang, Jin YoungPark, HyunwookLanger, RobertAnderson, DanielPark, Tae Gwan
Keywords
Bioactive polymers; Biocompatible polymer; Cell labeling; Effective dispersion; Hyaluronic acids; Iron oxide nanoparticle; iron oxide nanoparticles; Magnetic nanoparticles; Mesenchymal stem cell; Relaxivity; surface functionalization; Synthetic routes; Toxic reagents
Issue Date
201106
Publisher
AMER CHEMICAL SOC
Citation
ACS NANO, v.5, no.6, pp.4329 - 4336
Abstract
Currently available methods to stably disperse iron oxide nanoparticles (IONPs) in aqueous solution need to be improved due to potential aggregation, reduction of superparamagnetism, and the use of toxic reagents. Herein, we present a facile strategy for aqueous transfer and dispersion of organic-synthesized IONPs using only polyethylene glycol (PEG), a biocompatible polymer. A library of PEG derivatives was screened, and it was determined that amine-functionalized six-armed PEG, 6(PEG-NH(2)), was the most effective dispersion agent. The 6(PEG-NH(2))-modified IONPs (IONP-6PEG) were stable after extensive washing, exhibited high superparamagnetism, and could be used as a platform material for secondary surface functionalization with bioactive polymers. IONP-6PEG biofunctionalized with hyaluronic acid (IONP-6PEG-HA) was shown to specifically label mesenthymal stem cells and demonstrate MR contrast potential with high r(2) relaxivity (442.7 s(-1)mM(-1)) compared to the commercially available Feridex (182.1 s(-1)mM(-1)).
URI
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DOI
http://dx.doi.org/10.1021/nn201198f
ISSN
1936-0851
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