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dc.citation.endPage 742 -
dc.citation.number 4 -
dc.citation.startPage 731 -
dc.citation.title BIOMEDICAL MICRODEVICES -
dc.citation.volume 13 -
dc.contributor.author Tavana, Hossein -
dc.contributor.author Zamankhan, Parsa -
dc.contributor.author Christensen, Paul J. -
dc.contributor.author Grotberg, James B. -
dc.contributor.author Takayama, Shuichi -
dc.date.accessioned 2023-12-22T06:07:13Z -
dc.date.available 2023-12-22T06:07:13Z -
dc.date.created 2013-06-18 -
dc.date.issued 2011-08 -
dc.description.abstract Airways of the peripheral lung are prone to closure at low lung volumes. Deficiency or dysfunction of pulmonary surfactant during various lung diseases compounds this event by destabilizing the liquid lining of small airways and giving rise to occluding liquid plugs in airways. Propagation of liquid plugs in airways during inflation of the lung exerts large mechanical forces on airway cells. We describe a microfluidic model of small airways of the lung that mimics airway architecture, recreates physiologic levels of pulmonary pressures, and allows studying cellular response to repeated liquid plug propagation events. Substantial cellular injury happens due to the propagation of liquid plugs devoid of surfactant. We show that addition of a physiologic concentration of a clinical surfactant, Survanta, to propagating liquid plugs protects the epithelium and significantly reduces cell death. Although the protective role of surfactants has been demonstrated in models of a propagating air finger in liquid-filled airways, this is the first time to study the protective role of surfactants in liquid plugs where fluid mechanical stresses are expected to be higher than in air fingers. Our parallel computational simulations revealed a significant decrease in mechanical forces in the presence of surfactant, confirming the experimental observations. The results support the practice of providing exogenous surfactant to patients in certain clinical settings as a protective mechanism against pathologic flows. More importantly, this platform provides a useful model to investigate various surface tension-mediated lung diseases at the cellular level -
dc.identifier.bibliographicCitation BIOMEDICAL MICRODEVICES, v.13, no.4, pp.731 - 742 -
dc.identifier.doi 10.1007/s10544-011-9543-5 -
dc.identifier.issn 1387-2176 -
dc.identifier.scopusid 2-s2.0-80053895684 -
dc.identifier.uri https://scholarworks.unist.ac.kr/handle/201301/3603 -
dc.identifier.url http://www.scopus.com/inward/record.url?partnerID=HzOxMe3b&scp=80053895684 -
dc.identifier.wosid 000292556900014 -
dc.language 영어 -
dc.publisher SPRINGER -
dc.title Epithelium damage and protection during reopening of occluded airways in a physiologic microfluidic pulmonary airway model -
dc.type Article -
dc.relation.journalWebOfScienceCategory Engineering, Biomedical; Nanoscience & Nanotechnology -
dc.relation.journalResearchArea Engineering; Science & Technology - Other Topics -
dc.description.journalRegisteredClass scie -
dc.description.journalRegisteredClass scopus -
dc.subject.keywordAuthor Microfluidic airway model -
dc.subject.keywordAuthor Airway obstruction -
dc.subject.keywordAuthor Liquid plugs -
dc.subject.keywordAuthor Mechanical forces -
dc.subject.keywordAuthor Epithelium injury -
dc.subject.keywordAuthor Surfactant protection of cells -
dc.subject.keywordPlus RESPIRATORY-DISTRESS-SYNDROME -
dc.subject.keywordPlus IN-VITRO MODEL -
dc.subject.keywordPlus LUNG SURFACTANT -
dc.subject.keywordPlus PLASMA-MEMBRANE -
dc.subject.keywordPlus LIQUID PLUG -
dc.subject.keywordPlus CLOSURE -
dc.subject.keywordPlus CELLS -
dc.subject.keywordPlus INJURY -
dc.subject.keywordPlus MECHANICS -
dc.subject.keywordPlus TRANSPORT -

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