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Kim, Kyoung Taek
KT Kim Group at UNIST
Research Interests
  • Polymer Chemistry

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Glucose-Responsive Disassembly of Polymersomes of Sequence-Specific Boroxole-Containing Block Copolymers under Physiologically Relevant Conditions

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Title
Glucose-Responsive Disassembly of Polymersomes of Sequence-Specific Boroxole-Containing Block Copolymers under Physiologically Relevant Conditions
Author
Kim, HyunkyuKong, Young JiJeong, Eun SunKang, SebyungKim, Kyoung Taek
Keywords
BORONIC ACIDS; INSULIN; BINDING; RELEASE; CHAINS; WATER; PH
Issue Date
201210
Publisher
AMER CHEMICAL SOC
Citation
ACS MACRO LETTERS, v.1, no.10, pp.1194 - 1198
Abstract
Polymers containing organoboronic acids have recently gained interest as sugar-responsive materials owing to the reversible binding of saccharides to boronic acids, which triggers a change in the physical and chemical properties of these polymers, such as their water solubility. In particular, the ability of these polymers to bind glucose has attracted considerable attention because of the promise of these materials for the development of sensors and drug delivery systems for glucose-related human diseases, such as diabetes. We report here a new class of sugar-responsive polymers that are based on a sequence-specific copolymer of styreneboroxole and N-functionalized maleimide. The reversible addition-fragmentation and chain transfer (RAFT) polymerization of this pair of monomers ensured that a glucose receptor alternates with a nonresponsive solubilizing group throughout the sugar-responsive polymer chain. Due to the presence of hydrophilic solubilizing groups beween the solubility-switching boroxole moieties in the membrane-forming block, the polymersomes of the block copolymers responded to a lower level of glucose in the medium, resulting in diassembly of the bilayer membrane under a physiologically relevant pH and glucose level.
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DOI
http://dx.doi.org/10.1021/mz3004192
ISSN
2161-1653
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