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DC Field | Value | Language |
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dc.citation.endPage | 6367 | - |
dc.citation.number | 45 | - |
dc.citation.startPage | 6359 | - |
dc.citation.title | VACCINE | - |
dc.citation.volume | 30 | - |
dc.contributor.author | Do, Yoonkyung | - |
dc.contributor.author | Didierlaurent, Arnaud M. | - |
dc.contributor.author | Ryu, Seongho | - |
dc.contributor.author | Koh, Hyein | - |
dc.contributor.author | Park, Chae Gyu | - |
dc.contributor.author | Park, Steven | - |
dc.contributor.author | Perlin, David S. | - |
dc.contributor.author | Powell, Bradford S. | - |
dc.contributor.author | Steinman, Ralph M. | - |
dc.date.accessioned | 2023-12-22T04:41:14Z | - |
dc.date.available | 2023-12-22T04:41:14Z | - |
dc.date.created | 2013-06-18 | - |
dc.date.issued | 2012-10 | - |
dc.description.abstract | It is of great interest to develop a pneumonic plague vaccine that would induce combined humoral and cellular immunity in the lung. Here we investigate a novel approach based on targeting of dendritic cells using the DEC-205/CD205 receptor (DEC) via the intranasal route as way to improve mucosal cellular immunity to the vaccine. Intranasal administration of Yersinia pestis LcrV (V) protein fused to anti-DEC antibody together with poly IC as an adjuvant induced high frequencies of IFN-gamma secreting CD4(+) T cells in the airway and lung as well as pulmonary IgG and IgA antibodies. Anti-DEC:LcrV was more efficient to induce IFN-gamma/TNF-alpha/IL-2 secreting polyfunctional CD4(+) T cells when compared to non-targeted soluble protein vaccine. In addition, the intranasal route of immunization with anti-DEC:LcrV was associated with improved survival upon pulmonary challenge with the virulent CO92 Y. pestis. Taken together, these data indicate that targeting dendritic cells via the mucosal route is a potential new avenue for the development of a mucosal vaccine against pneumonic plague. | - |
dc.identifier.bibliographicCitation | VACCINE, v.30, no.45, pp.6359 - 6367 | - |
dc.identifier.doi | 10.1016/j.vaccine.2012.08.051 | - |
dc.identifier.issn | 0264-410X | - |
dc.identifier.scopusid | 2-s2.0-84866547636 | - |
dc.identifier.uri | https://scholarworks.unist.ac.kr/handle/201301/3568 | - |
dc.identifier.url | http://www.scopus.com/inward/record.url?partnerID=HzOxMe3b&scp=84866547636 | - |
dc.identifier.wosid | 000310117200003 | - |
dc.language | 영어 | - |
dc.publisher | ELSEVIER SCI LTD | - |
dc.title | Induction of pulmonary mucosal immune responses with a protein vaccine targeted to the DEC-205/CD205 receptor | - |
dc.type | Article | - |
dc.relation.journalWebOfScienceCategory | Immunology; Medicine, Research & Experimental | - |
dc.relation.journalResearchArea | Immunology; Research & Experimental Medicine | - |
dc.description.journalRegisteredClass | scie | - |
dc.description.journalRegisteredClass | scopus | - |
dc.subject.keywordAuthor | Dendritic cells | - |
dc.subject.keywordAuthor | CD205/DEC-205 | - |
dc.subject.keywordAuthor | Y. pestis | - |
dc.subject.keywordAuthor | LcrV | - |
dc.subject.keywordAuthor | Cellular immunity | - |
dc.subject.keywordAuthor | Mucosal | - |
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