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Author

Do, Yoonkyung
DC-based Immune System & Immunotherapy (DISNI) Lab
Research Interests
  • Study on various subsets of dendritic cells and their immunological functions

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Induction of pulmonary mucosal immune responses with a protein vaccine targeted to the DEC-205/CD205 receptor

Cited 0 times inthomson ciCited 7 times inthomson ci
Title
Induction of pulmonary mucosal immune responses with a protein vaccine targeted to the DEC-205/CD205 receptor
Author
Do, YoonkyungDidierlaurent, Arnaud M.Ryu, SeonghoKoh, HyeinPark, Chae GyuPark, StevenPerlin, David S.Powell, Bradford S.Steinman, Ralph M.
Keywords
CD205/DEC-205; Cellular immunity; Dendritic cells; LcrV; Mucosal; Y. pestis
Issue Date
201210
Publisher
ELSEVIER SCI LTD
Citation
VACCINE, v.30, no.45, pp.6359 - 6367
Abstract
It is of great interest to develop a pneumonic plague vaccine that would induce combined humoral and cellular immunity in the lung. Here we investigate a novel approach based on targeting of dendritic cells using the DEC-205/CD205 receptor (DEC) via the intranasal route as way to improve mucosal cellular immunity to the vaccine. Intranasal administration of Yersinia pestis LcrV (V) protein fused to anti-DEC antibody together with poly IC as an adjuvant induced high frequencies of IFN-gamma secreting CD4(+) T cells in the airway and lung as well as pulmonary IgG and IgA antibodies. Anti-DEC:LcrV was more efficient to induce IFN-gamma/TNF-alpha/IL-2 secreting polyfunctional CD4(+) T cells when compared to non-targeted soluble protein vaccine. In addition, the intranasal route of immunization with anti-DEC:LcrV was associated with improved survival upon pulmonary challenge with the virulent CO92 Y. pestis. Taken together, these data indicate that targeting dendritic cells via the mucosal route is a potential new avenue for the development of a mucosal vaccine against pneumonic plague.
URI
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DOI
http://dx.doi.org/10.1016/j.vaccine.2012.08.051
ISSN
0264-410X
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