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Author

Park, Chan Young
Calcium Dynamics Lab
Research Interests
  • Calcium Signaling, calcium Channels, immune, neuroscience, drug Development

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The CRAC channel activator STIM1 binds and inhibits L-type voltage-gated calcium channels

Cited 0 times inthomson ciCited 102 times inthomson ci
Title
The CRAC channel activator STIM1 binds and inhibits L-type voltage-gated calcium channels
Author
Park, Chan YoungShcheglovitov, AleksandrDolmetsch, Ricardo
Keywords
MEDIUM SPINY NEURONS; T-LYMPHOCYTES; SKELETAL-MUSCLE; PLASMA-MEMBRANE; CA2+ CHANNELS; STORE; ENTRY; ORAI1; INFLUX; SENSOR
Issue Date
201010
Publisher
AMER ASSOC ADVANCEMENT SCIENCE
Citation
SCIENCE, v.330, no.6000, pp.101 - 105
Abstract
Voltage-and store-operated calcium (Ca(2+)) channels are the major routes of Ca(2+) entry in mammalian cells, but little is known about how cells coordinate the activity of these channels to generate coherent calcium signals. We found that STIM1 (stromal interaction molecule 1), the main activator of store-operated Ca(2+) channels, directly suppresses depolarization-induced opening of the voltage-gated Ca(2+) channel Ca(V)1.2. STIM1 binds to the C terminus of Ca(V)1.2 through its Ca(2+) release-activated Ca(2+) activation domain, acutely inhibits gating, and causes long-term internalization of the channel from the membrane. This establishes a previously unknown function for STIM1 and provides a molecular mechanism to explain the reciprocal regulation of these two channels in cells.
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DOI
http://dx.doi.org/10.1126/science.1191027
ISSN
0036-8075
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