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Madou, Mark
BIO-MEMS Lab
Research Interests
  • Medical Diagnostics

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Suction-enhanced siphon valves for centrifugal microfluidic platforms

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Title
Suction-enhanced siphon valves for centrifugal microfluidic platforms
Author
Gorkin, RobertSoroori, SalarSouthard, WilliamClime, LiviuVeres, TeodorKido, HoracioKulinsky, LawrenceMadou, Marc
Keywords
Centrifugal microfluidics; Centrifugal suction effect; Siphoning; Suction-enhanced siphoning; Valving
Issue Date
201201
Publisher
SPRINGER HEIDELBERG
Citation
MICROFLUIDICS AND NANOFLUIDICS, v.12, no.41278, pp.345 - 354
Abstract
In traditional centrifugal microfluidic platforms pumping is restricted to outward fluid flow, resulting in potential real estate issues for embedding complex microsystems. To overcome the limitation, researchers utilize hydrophilic channels to force liquids short distances back toward the disk center. However, most polymers used for CD fabrication are natively hydrophobic, and creating hydrophilic conditions requires surface treatments/specialized materials that pose unique challenges to manufacturing and use. This work describes a novel technology that enjoys the advantages of hydrophilic fluidics on a hydrophobic disk device constructed from untreated polycarbonate plastic. The method, termed suction-enhanced siphoning, is based on exploiting the non-linear hydrostatic pressure profile and related pressure drop created along the length of a rotating microchannel. Theoretical analysis as well as experimental validation of the system is provided. In addition, we demonstrate the use of the hydrostatic pressure pump as a new method for priming hydrophobic-based siphon structures. The development of such techniques for hydrophobic fluidics advances the capabilities of the centrifugal microfluidic platform while remaining true to the goal of creating disposable polymer devices using feasible manufacturing schemes.
URI
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DOI
http://dx.doi.org/10.1007/s10404-011-0878-2
ISSN
1613-4982
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