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Author

Takayama, Shuichi
Cell and Microfluidics Lab
Research Interests
  • Bio-MEMS and Microfluidics

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Organs-on-a-Chip: A Focus on Compartmentalized Microdevices

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Title
Organs-on-a-Chip: A Focus on Compartmentalized Microdevices
Author
Moraes, ChristopherMehta, GeetaLesher-Perez, Sasha CaiTakayama, Shuichi
Keywords
Barrier; Compartment; Micro-engineering; Microenvironments; Microtechnology; Organ
Issue Date
201206
Publisher
SPRINGER
Citation
ANNALS OF BIOMEDICAL ENGINEERING, v.40, no.6, pp.1211 - 1227
Abstract
Advances in microengineering technologies have enabled a variety of insights into biomedical sciences that would not have been possible with conventional techniques. Engineering microenvironments that simulate in vivo organ systems may provide critical insight into the cellular basis for pathophysiologies, development, and homeostasis in various organs, while curtailing the high experimental costs and complexities associated with in vivo studies. In this article, we aim to survey recent attempts to extend tissue-engineered platforms toward simulating organ structure and function, and discuss the various approaches and technologies utilized in these systems. We specifically focus on microtechnologies that exploit phenomena associated with compartmentalization to create model culture systems that better represent the in vivo organ microenvironment
URI
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DOI
http://dx.doi.org/10.1007/s10439-011-0455-6
ISSN
0090-6964
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