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Author

Takayama, Shuichi
Cell and Microfluidics Lab
Research Interests
  • Bio-MEMS and Microfluidics

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Nanoscale Squeezing in Elastomeric Nanochannels for Single Chromatin Linearization

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Title
Nanoscale Squeezing in Elastomeric Nanochannels for Single Chromatin Linearization
Author
Matsuoka, ToshikiKim, Byoung ChoulHuang, JiexiDouville, Nicholas JosephThouless, M. D.Takayama, Shuichi
Keywords
Epigenetics; Hydrodynamic flows; Nano channels; Nano scale; Nanoconfinements; Unique features
Issue Date
201212
Publisher
AMER CHEMICAL SOC
Citation
NANO LETTERS, v.12, no.12, pp.6480 - 6484
Abstract
This paper describes a novel nanofluidic phenomenon where untethered DNA and chromatin are linearized by rapidly narrowing an elastomeric nanochannel filled with solutions of the biopolymers. This nanoscale squeezing procedure generates hydrodynamic flows while also confining the biopolymers into smaller and smaller volumes. The unique features of this technique enable full linearization then trapping of biopolyrners such as DNA. The versatility of the method is also demonstrated by analysis of chromatin stretchability and mapping of histone states using single strands of chromatin
URI
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DOI
http://dx.doi.org/10.1021/nl304063f
ISSN
1530-6984
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