BROWSE

Related Researcher

Author

Takayama, Shuichi
Cell and Microfluidics Lab
Research Interests
  • Bio-MEMS and Microfluidics

ITEM VIEW & DOWNLOAD

Opportunities and challenges for use of tumor spheroids as models to test drug delivery and efficacy

Cited 0 times inthomson ciCited 42 times inthomson ci
Title
Opportunities and challenges for use of tumor spheroids as models to test drug delivery and efficacy
Author
Mehta, GeetaHsiao, Amy Y.Ingram, MarylouLuker, Gary D.Takayama, Shuichi
Keywords
Coculture; Drug delivery system; Drug penetration; Drug screening; Drug testing; Extracellular matrix deposition; High throughput; In-vitro; In-vivo; Micro-scales; Multi-cellular architectures; Multicellular spheroid; Pathological tissue; Physiologic parameters; Spheroids; Target cells; Tumor spheroid
Issue Date
201212
Publisher
ELSEVIER SCIENCE BV
Citation
JOURNAL OF CONTROLLED RELEASE, v.164, no.2, pp.192 - 204
Abstract
Multicellular spheroids are three dimensional in vitro microscale tissue analogs. The current article examines the suitability of spheroids as an in vitro platform for testing drug delivery systems. Spheroids model critical physiologic parameters present in vivo, including complex multicellular architecture, barriers to mass transport, and extracellular matrix deposition. Relative to two-dimensional cultures, spheroids also provide better target cells for drug testing and are appropriate in vitro models for studies of drug penetration. Key challenges associated with creation of uniformly sized spheroids, spheroids with small number of cells and co-culture spheroids are emphasized in the article. Moreover, the assay techniques required for the characterization of drug delivery and efficacy in spheroids and the challenges associated with such studies are discussed. Examples for the use of spheroids in drug delivery and testing are also emphasized. By addressing these challenges with possible solutions, multicellular spheroids are becoming an increasingly useful in vitro tool for drug screening and delivery to pathological tissues and organs
URI
Go to Link
DOI
http://dx.doi.org/10.1016/j.jconrel.2012.04.045
ISSN
0168-3659
Appears in Collections:
SLS_Journal Papers

find_unist can give you direct access to the published full text of this article. (UNISTARs only)

Show full item record

qr_code

  • mendeley

    citeulike

Items in DSpace are protected by copyright, with all rights reserved, unless otherwise indicated.

MENU