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Author

Takayama, Shuichi
Cell and Microfluidics Lab
Research Interests
  • Bio-MEMS and Microfluidics

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Microfluidic systems: A new toolbox for pluripotent stem cells

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Title
Microfluidic systems: A new toolbox for pluripotent stem cells
Author
Lesher-Perez, Sasha CaiFrampton, John P.Takayama, Shuichi
Keywords
Clinical use;  Culture systems;  Dynamic features;  Embryonic stem cells;  Extracellular;  Growth conditions;  In-vitro;  In-vivo;  Mechanical stimulation;  Micro fluidic system;  Microscale patterning;  Pluripotent stem cells;  Stem-cell niches
Issue Date
201302
Publisher
WILEY-BLACKWELL
Citation
BIOTECHNOLOGY JOURNAL, v.8, no.2, pp.180 - 191
Abstract
Conventional culture systems are often limited in their ability to regulate the growth and differentiation of pluripotent stem cells. Microfluidic systems can overcome some of these limitations by providing defined growth conditions with user-controlled spatiotemporal cues. Microfluidic systems allow researchers to modulate pluripotent stem cell renewal and differentiation through biochemical and mechanical stimulation, as well as through microscale patterning and organization of cells and extracellular materials. Essentially, microfluidic tools are reducing the gap between in vitro cell culture environments and the complex and dynamic features of the in vivo stem cell niche. These microfluidic culture systems can also be integrated with microanalytical tools to assess the health and molecular status of pluripotent stem cells. The ability to control biochemical and mechanical input to cells, as well as rapidly and efficiently analyze the biological output from cells, will further our understanding of stem cells and help translate them into clinical use. This review provides a comprehensive insignt into the implications of microfluidics on pluripotent stem cell research.
URI
http://scholarworks.unist.ac.kr/handle/201301/3486
DOI
http://dx.doi.org/10.1002/biot.201200206
ISSN
1860-6768
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SLS_Journal Papers
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