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Author

Takayama, Shuichi
Cell and Microfluidics Lab
Research Interests
  • Bio-MEMS and Microfluidics

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Large-Scale, Ultrapliable, and Free-Standing Nanomembranes

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Title
Large-Scale, Ultrapliable, and Free-Standing Nanomembranes
Author
Kang, EdwardRyoo, JiheeJeong, Gi SeokChoi, Yoon YoungJeong, Seung MinJu, JongilChung, SeokTakayama, ShuichiLee, Sang-Hoon
Keywords
Cell monolayers; Epithelial monolayers; Free-standing nanomembranes; Nanomembranes; PDMS membrane; Tight junctions; Ultra-thin; Ultra-thin membranes
Issue Date
201304
Publisher
WILEY-V C H VERLAG GMBH
Citation
ADVANCED MATERIALS, v.25, no.15, pp.2167 - 2173
Abstract
The creation and characterization of large-area ultrathin highly pliable free-standing PDMS membranes and their application to the study of cellular epithelia is described. The ultra-thin membranes permitted the straight forward calculation of cell monolayer moduli, derived from measured stress-strain curves. These measurements allowed the unprecedented detection of cellular-level injury in the epithelia caused by the rupture of cell-cell tight junctions in response to stretching.
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DOI
http://dx.doi.org/10.1002/adma.201204619
ISSN
0935-9648
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