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Author

Kang, Sebyung
Protein Nanobio Lab
Research Interests
  • Protein engineering, Drug/diagnostics delivery nanoplatform, Protein-base vaccine delivery systems, Biosensor & imaging

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Site-Directed Coordination Chemistry with P22 Virus-like Particles

Cited 0 times inthomson ciCited 6 times inthomson ci
Title
Site-Directed Coordination Chemistry with P22 Virus-like Particles
Author
Uchida, MasakiMorris, David SKang, SebyungJolley, Craig CLucon, JaniceLiepold, Lars OLaFrance, BenPrevelige, Peter E., Jr.Douglas, Trevor
Keywords
Analytical ultracentrifugation; Cargo molecules; Coordination bonds; Coordination chemistry; Directed synthesis; Functionalizations; Guest molecules; Guest species; Interior surfaces; Kinetic stability; Macromolecular coordination; Multiangle laser light scattering; Protein cages; Salmonella Typhimurium; Site-specific; Small molecules; Virus-like particles
Issue Date
201201
Publisher
AMER CHEMICAL SOC
Citation
LANGMUIR, v.28, no.4, pp.1998 - 2006
Abstract
Protein cage nanoparticles (PCNs) are attractive platforms for developing functional nanomaterials using biomimetic approaches for functionalization and cargo encapsulation. Many strategies have been employed to direct the loading of molecular cargos inside a wide range of PCN architectures. Here we demonstrate the exploitation of a metal-ligand coordination bond with respect to the direct packing of guest molecules on the interior interface of a virus-like PCN derived from Salmonella typhimurium bacteriophage P22. The incorporation of these guest species was assessed using mass spectrometry, multiangle laser light scattering, and analytical ultracentrifugation. In addition to small-molecule encapsulation, this approach was also effective for the directed synthesis of a large macromolecular coordination polymer packed inside of the P22 capsid and initiated on the interior surface. A wide range of metals and ligands with different thermodynamic affinities and kinetic stabilities are potentially available for this approach, highlighting the potential for metal-ligand coordination chemistry to direct the site-specific incorporation of cargo molecules for a variety of applications.
URI
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DOI
http://dx.doi.org/10.1021/la203866c
ISSN
0743-7463
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