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Author

Kim, Byeong-Su
Soft and Hybrid Nanomaterials Lab
Research Interests
  • Carbon materials, polymer, Layer-by-Layer (LbL) assembly, hyperbranched polymer, polyglycerol (PG), bio-applications

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Hyperbranched Double Hydrophilic Block Copolymer Micelles of Poly(ethylene oxide) and Polyglycerol for pH-Responsive Drug Delivery

Cited 0 times inthomson ciCited 28 times inthomson ci
Title
Hyperbranched Double Hydrophilic Block Copolymer Micelles of Poly(ethylene oxide) and Polyglycerol for pH-Responsive Drug Delivery
Author
Lee, SueunSaito, KyoheiLee, Hye-RaLee, Min JaeShibasaki, YujiOishi, YoshiyuldKim, Byeong-Su
Keywords
Anti-cancer agents; Average size; Controlled release; Core-shell; Double-hydrophilic block copolymers; Doxorubicin; Drug delivery system; Drug release; Drug-loading efficiency; Efficient drug delivery; Enhanced efficiency; Ethylene oxides; Hydrazone bonds; Hyperbranched; In-vitro; Micellar structures; pH sensitive; PH-responsive; Polyglycerols; Self-assembled; Stimuli-responsive; Water solubilities
Issue Date
201204
Publisher
AMER CHEMICAL SOC
Citation
BIOMACROMOLECULES, v.13, no.4, pp.1190 - 1196
Abstract
We report the synthesis of a well-defined hyperbranched double hydrophilic block copolymer of poly(ethylene oxide)-hyperbranched-polyglycerol (PEO-hb-PG) to develop an efficient drug delivery system. In specific, we demonstrate the hyperbranched PEO-hb-PG can form a self-assembled micellar structure on conjugation with the hydrophobic anticancer agent doxorubicin, which is linked to the polymer by pH-sensitive hydrazone bonds, resulting in a pH-responsive controlled release of doxorubicin. Dynamic light scattering, atomic force microscopy, and transmission electron microscopy demonstrated successful formation of the spherical core-shell type micelles with an average size of about 200 nm. Moreover, the pH-responsive release of doxorubicin and in vitro cytotoxicity studies revealed the controlled stimuli-responsive drug delivery system desirable for enhanced efficiency. Benefiting from many desirable features of hyperbranched double hydrophilic block copolymers such as enhanced biocompatibility, increased water solubility, and drug loading efficiency as well as improved clearance of the polymer after drug release, we believe that double hydrophilic block copolymer will provide a versatile platform to develop excellent drug delivery systems for effective treatment of cancer.
URI
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DOI
http://dx.doi.org/10.1021/bm300151m
ISSN
1525-7797
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