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Suh, Pann-Ghill
BioSignal Network Lab (BSN)
Research Interests
  • Signal transduction, cancer, metabolism, phospholipase C

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DJ-1 promotes angiogenesis and osteogenesis by activating FGF receptor-1 signaling

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Title
DJ-1 promotes angiogenesis and osteogenesis by activating FGF receptor-1 signaling
Author
Kim, Jung-MinShin, Hong-InCha, Sun-ShinLee, Chang SupHong, Bok SilLim, SeyoungJang, Hyun-JunKim, JaeyoonYang, Yong RyoulKim, Yun-HeeYun, SangukRijal, GirdhariLee-Kwon, WhaseonSeo, Jeong KonGho, Yong SongRyu, Sung HoHur, Eun-MiSuh, Pann-Ghill
Keywords
ENDOTHELIAL-GROWTH-FACTOR; BONE MORPHOGENETIC PROTEIN-4; PARKINSONS-DISEASE; OXIDATIVE STRESS; DEFECT MODEL; CELLS; VEGF; REGENERATION; EXPRESSION; PATHWAYS
Issue Date
201212
Publisher
NATURE PUBLISHING GROUP
Citation
NATURE COMMUNICATIONS, v.3, no., pp.1 - 11
Abstract
Communication between osteoblasts and endothelial cells is essential for bone fracture repair, but the molecular identities of such communicating factors are not well defined. Here we identify DJ-1 as a novel mediator of the cross-talk between osteoblasts and endothelial cells through an unbiased screening of molecules secreted from human mesenchymal stem cells during osteogenesis. We show that DJ-1 stimulates the differentiation of human mesenchymal stem cells to osteoblasts and that DJ-1 induces angiogenesis in endothelial cells through activation of fibroblast growth factor receptor-1 signalling. In a rodent model of bone fracture repair, extracellular application of DJ-1 enhances bone regeneration in vivo by stimulating the formation of blood vessels and new bones. Both these effects are blocked by antagonizing fibroblast growth factor receptor-1 signalling. These findings uncover previously undefined extracellular roles of DJ-1 to promote angiogenesis and osteogenesis, suggesting DJ-1 may have therapeutic potential to stimulate bone regeneration.
URI
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DOI
http://dx.doi.org/10.1038/ncomms2313
ISSN
2041-1723
Appears in Collections:
UCRF_Journal Papers
SLS_Journal Papers

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