DJ-1 promotes angiogenesis and osteogenesis by activating FGF receptor-1 signaling
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- DJ-1 promotes angiogenesis and osteogenesis by activating FGF receptor-1 signaling
- Kim, Jung-Min; Shin, Hong-In; Cha, Sun-Shin; Lee, Chang Sup; Hong, Bok Sil; Lim, Seyoung; Jang, Hyun-Jun; Kim, Jaeyoon; Yang, Yong Ryoul; Kim, Yun-Hee; Yun, Sanguk; Rijal, Girdhari; Lee-Kwon, Whaseon; Seo, Jeong Kon; Gho, Yong Song; Ryu, Sung Ho; Hur, Eun-Mi; Suh, Pann-Ghill
- ENDOTHELIAL-GROWTH-FACTOR; BONE MORPHOGENETIC PROTEIN-4; PARKINSONS-DISEASE; OXIDATIVE STRESS; DEFECT MODEL; CELLS; VEGF; REGENERATION; EXPRESSION; PATHWAYS
- Issue Date
- NATURE PUBLISHING GROUP
- NATURE COMMUNICATIONS, v.3, no., pp.1 - 11
- Communication between osteoblasts and endothelial cells is essential for bone fracture repair, but the molecular identities of such communicating factors are not well defined. Here we identify DJ-1 as a novel mediator of the cross-talk between osteoblasts and endothelial cells through an unbiased screening of molecules secreted from human mesenchymal stem cells during osteogenesis. We show that DJ-1 stimulates the differentiation of human mesenchymal stem cells to osteoblasts and that DJ-1 induces angiogenesis in endothelial cells through activation of fibroblast growth factor receptor-1 signalling. In a rodent model of bone fracture repair, extracellular application of DJ-1 enhances bone regeneration in vivo by stimulating the formation of blood vessels and new bones. Both these effects are blocked by antagonizing fibroblast growth factor receptor-1 signalling. These findings uncover previously undefined extracellular roles of DJ-1 to promote angiogenesis and osteogenesis, suggesting DJ-1 may have therapeutic potential to stimulate bone regeneration.
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