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DC Field | Value | Language |
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dc.citation.endPage | 5742 | - |
dc.citation.number | 8 | - |
dc.citation.startPage | 5732 | - |
dc.citation.title | JOURNAL OF BIOLOGICAL CHEMISTRY | - |
dc.citation.volume | 288 | - |
dc.contributor.author | Song, Parkyong | - |
dc.contributor.author | Kim, Jong Hyun | - |
dc.contributor.author | Ghim, Jaewang | - |
dc.contributor.author | Yoon, Jong Hyuk | - |
dc.contributor.author | Lee, Areum | - |
dc.contributor.author | Kwon, Yonghoon | - |
dc.contributor.author | Hyun, Hyunjung | - |
dc.contributor.author | Moon, Hyo-Youl | - |
dc.contributor.author | Choi, Hueng-Sik | - |
dc.contributor.author | Berggren, Per-Olof | - |
dc.contributor.author | Suh, Pann-Ghill | - |
dc.contributor.author | Ryu, Sung Ho | - |
dc.date.accessioned | 2023-12-22T04:13:12Z | - |
dc.date.available | 2023-12-22T04:13:12Z | - |
dc.date.created | 2013-06-28 | - |
dc.date.issued | 2013-02 | - |
dc.description.abstract | AMP-activated protein kinase has been described as a key signaling protein that can regulate energy homeostasis. Here, we aimed to characterize novel AMP-activated kinase (AMPK)-activating compounds that have a much lower effective concentration than metformin. As a result, emodin, a natural anthraquinone derivative, was shown to stimulate AMPK activity in skeletal muscle and liver cells. Emodin enhanced GLUT4 translocation and [C-14]glucose uptake into the myotube in an AMPK-dependent manner. Also, emodin inhibited glucose production by suppressing the expression of key gluconeogenic genes, such as phosphoenolpyruvate carboxykinase and glucose-6-phosphatase, in hepatocytes. Furthermore, we found that emodin can activate AMPK by inhibiting mitochondrial respiratory complex I activity, leading to increased reactive oxygen species and Ca2+/calmodulin-dependent protein kinase kinase activity. Finally, we confirmed that a single dose administration of emodin significantly decreased the fasting plasma glucose levels and improved glucose tolerance in C57Bl/6J mice. Increased insulin sensitivity was also confirmed after daily injection of emodin for 8 days using an insulin tolerance test and insulin-stimulated PI3K phosphorylation in wild type and high fat diet-induced diabetic mouse models. Our study suggests that emodin regulates glucose homeostasis in vivo by AMPK activation and that this may represent a novel therapeutic principle in the treatment of type 2 diabetic models. | - |
dc.identifier.bibliographicCitation | JOURNAL OF BIOLOGICAL CHEMISTRY, v.288, no.8, pp.5732 - 5742 | - |
dc.identifier.doi | 10.1074/jbc.M112.441477 | - |
dc.identifier.issn | 0021-9258 | - |
dc.identifier.scopusid | 2-s2.0-84874314479 | - |
dc.identifier.uri | https://scholarworks.unist.ac.kr/handle/201301/3395 | - |
dc.identifier.url | http://www.scopus.com/inward/record.url?partnerID=HzOxMe3b&scp=84874314479 | - |
dc.identifier.wosid | 000315342500045 | - |
dc.language | 영어 | - |
dc.publisher | AMER SOC BIOCHEMISTRY MOLECULAR BIOLOGY INC | - |
dc.title | Emodin Regulates Glucose Utilization by Activating AMP-activated Protein Kinase | - |
dc.type | Article | - |
dc.relation.journalWebOfScienceCategory | Biochemistry & Molecular Biology | - |
dc.relation.journalResearchArea | Biochemistry & Molecular Biology | - |
dc.description.journalRegisteredClass | scie | - |
dc.description.journalRegisteredClass | scopus | - |
dc.subject.keywordPlus | 11-BETA-HYDROXYSTEROID DEHYDROGENASE TYPE-1 | - |
dc.subject.keywordPlus | DEPENDENT DIABETES-MELLITUS | - |
dc.subject.keywordPlus | RAT SKELETAL-MUSCLE | - |
dc.subject.keywordPlus | COMPLEX-I | - |
dc.subject.keywordPlus | SIGNALING PATHWAY | - |
dc.subject.keywordPlus | ADIPOSE-TISSUE | - |
dc.subject.keywordPlus | INSULIN | - |
dc.subject.keywordPlus | METFORMIN | - |
dc.subject.keywordPlus | CELLS | - |
dc.subject.keywordPlus | TRANSPORT | - |
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