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Madou, Mark
BIO-MEMS Lab
Research Interests
  • Medical Diagnostics

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Theoretical development and critical analysis of burst frequency equations for passive valves on centrifugal microfluidic platforms

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Title
Theoretical development and critical analysis of burst frequency equations for passive valves on centrifugal microfluidic platforms
Author
Thio, Tzer Hwai GilbertSoroori, SalarIbrahim, FatimahAl-Faqheri, WisamSoin, NorhayatiKulinsky, LawrenceMadou, Marc
Keywords
Burst frequency equation; Centrifugal; Compact disc (CD); Microfluidics; Passive valve
Issue Date
201305
Publisher
SPRINGER HEIDELBERG
Citation
MEDICAL & BIOLOGICAL ENGINEERING & COMPUTING, v.51, no.5, pp.525 - 535
Abstract
This paper presents a theoretical development and critical analysis of the burst frequency equations for capillary valves on a microfluidic compact disc (CD) platform. This analysis includes background on passive capillary valves and the governing models/equations that have been developed to date. The implicit assumptions and limitations of these models are discussed. The fluid meniscus dynamics before bursting is broken up into a multi-stage model and a more accurate version of the burst frequency equation for the capillary valves is proposed. The modified equations are used to evaluate the effects of various CD design parameters such as the hydraulic diameter, the height to width aspect ratio, and the opening wedge angle of the channel on the burst pressure.
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DOI
http://dx.doi.org/10.1007/s11517-012-1020-7
ISSN
0140-0118
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