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Inducible Biosynthetic Nanoscaffolds as Recruitment Platforms for Detecting Molecular Target Interactions inside Living Cells

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Title
Inducible Biosynthetic Nanoscaffolds as Recruitment Platforms for Detecting Molecular Target Interactions inside Living Cells
Author
Lee, SangkyuHa, Jae-SeokLee, Seung-GooKim, Tae K.
Keywords
High sensitivity; Living cell; Molecular targets; Nanoscaffolds; Single-cell level; Small molecules; Supramolecular assemblies; Target proteins
Issue Date
201207
Publisher
AMER CHEMICAL SOC
Citation
JOURNAL OF THE AMERICAN CHEMICAL SOCIETY, v.134, no.28, pp.11346 - 11349
Abstract
We present a novel phenotypic readout using inducible, biosynthetic nanoscaffolds to directly visualize dynamic molecular interactions within living cells at the single-cell level with high sensitivity and selectivity. Labeled ferritin is used to form biological nanoparticles inside cells. Specific supramolecular assembly of ferritin-derived nanoparticles induces highly clustered nanoscaffolds. These inducible biosynthetic nanoscaffolds are used as the artificial recruitment/redistribution platform for monitoring interactions of a small molecule with its target protein(s) inside living cells.
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DOI
http://dx.doi.org/10.1021/ja303518d
ISSN
0002-7863
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