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Author

Takayama, Shuichi
Cell and Microfluidics Lab
Research Interests
  • Bio-MEMS and Microfluidics

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Lab-on-a-chip biophotonics: its application to assisted reproductive technologies

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Title
Lab-on-a-chip biophotonics: its application to assisted reproductive technologies
Author
Lai, DavidSmith, Gary D.Takayama, Shuichi
Keywords
Assisted reproductive technologies; Bio photonics; Broad spectrum; Lab on a chip; Metabolite analysis; Off-chip; Optoelectrical; Predictive power; Reproductive potential
Issue Date
201208
Publisher
WILEY-V C H VERLAG GMBH
Citation
JOURNAL OF BIOPHOTONICS, v.5, no.8-9, pp.650 - 660
Abstract
With the benefits of automation, sensitivity and precision, microfluidics has enabled complex and otherwise tedious experiments. Lately, lab-on-a-chip (LOC) has proven to be a useful tool for enhancing non-invasive assisted reproductive technology (ART). Non-invasive gamete and embryo assessment has largely been through periodic morpohological assessment using optical microscopy and early LOC ART was the same. As we realize that morphological assessment is a poor indication of gamete or embryo health, more advanced biophotonics has emerged in LOC ART to assay for metabolites or gamete separation via optoelectrical tweezers. Off-chip, even more advanced biophotonics with broad spectrum analysis of metabolites and secretomes has been developed that show even higher accuracy to predicting reproductive potential. The integration of broad spectrum metabolite analysis into LOC ART is an exciting future that merges automation and sensitivity with the already highly accurate and strong predictive power of biophotonics
URI
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DOI
http://dx.doi.org/10.1002/jbio.201200041
ISSN
1864-063X
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