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Suh, Pann-Ghill
BioSignal Network Lab (BSN)
Research Interests
  • Signal transduction, cancer, metabolism, phospholipase C

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Phospholipase signalling networks in cancer

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Title
Phospholipase signalling networks in cancer
Author
Park, Jong BaeLee, Chang SupJang, Jin-HyeokGhim, JaewangKim, Youn-JaeYou, SungyoungHwang, DaeheeSuh, Pann-GhillRyu, Sung Ho
Keywords
ENDOTHELIAL-GROWTH-FACTOR; PROTEIN-KINASE-C; IIA SECRETORY PHOSPHOLIPASE-A2; PLECKSTRIN HOMOLOGY DOMAIN; SKIN TUMOR-DEVELOPMENT; BREAST-CANCER; LYSOPHOSPHATIDIC ACID; PHOSPHATIDIC-ACID; OVARIAN-CANCER; COLON TUMORIGENESIS
Issue Date
201211
Publisher
NATURE PUBLISHING GROUP
Citation
NATURE REVIEWS CANCER, v.12, no.11, pp.782 - 792
Abstract
Phospholipases (PLC, PLD and PLA) are essential mediators of intracellular and intercellular signalling. They can function as phospholipid-hydrolysing enzymes that can generate many bioactive lipid mediators, such as diacylglycerol, phosphatidic acid, lysophosphatidic acid and arachidonic acid. Lipid mediators generated by phospholipases regulate multiple cellular processes that can promote tumorigenesis, including proliferation, migration, invasion and angiogenesis. Although many individual phospholipases have been extensively studied, how phospholipases regulate diverse cancer-associated cellular processes and the interplay between different phospholipases have yet to be fully elucidated. A thorough understanding of the cancer-associated signalling networks of phospholipases is necessary to determine whether these enzymes can be targeted therapeutically.
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DOI
http://dx.doi.org/10.1038/nrc3379
ISSN
1474-175X
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