File Download

There are no files associated with this item.

  • Find it @ UNIST can give you direct access to the published full text of this article. (UNISTARs only)
Related Researcher

서판길

Suh, Pann-Ghill
Read More

Views & Downloads

Detailed Information

Cited time in webofscience Cited time in scopus
Metadata Downloads

Full metadata record

DC Field Value Language
dc.citation.endPage 030 -
dc.citation.number 1 -
dc.citation.startPage 023 -
dc.citation.title Journal of Cancer Science and Therapy -
dc.citation.volume 5 -
dc.contributor.author Kim, Kwang-Youn -
dc.contributor.author Seo, Young Kyo -
dc.contributor.author Yu, Sun-Nyoung -
dc.contributor.author Kim, Sang-Hun -
dc.contributor.author Suh, Pann-Ghill -
dc.contributor.author Ji, Jae-Hoon -
dc.contributor.author Yu, Hak-Sun -
dc.contributor.author Park, Yeong-Min -
dc.contributor.author Ahn, Soon-Cheol -
dc.date.accessioned 2023-12-22T03:12:16Z -
dc.date.available 2023-12-22T03:12:16Z -
dc.date.created 2013-07-03 -
dc.date.issued 2013-12 -
dc.description.abstract Previously, we reported that salinomycin induces apoptosis of human prostate cancer cells through accumulated reactive oxygen species and mitochondrial membrane depolarization. To extend our understanding for the genomewide expression pattern, we performed cDNA microarray analysis for gene expression profiles in prostate PC-3 cells treated with salinomycin. We found a couple of differences from gene expression profiles. First of them, cyclins and cyclin-dependent kinases were down-regulated, whereas cyclin dependent kinase inhibitors were upregulated, implicating inhibition of cell cycle progression. Second, HSPA5/Bip, DDIT3/CHOP, TRIB3, ATF4 and ATF6 regarding endoplasmic reticulum (ER) stress and unfolded protein response (UPR) were increased at mRNA and protein levels, indicating salinomycin-induced growth inhibition of PC-3 cells seem to be mediated through induction of ER stress and activation of the UPR pathway. Our finding should be useful for understanding genomewide expression patterns of salinomycin-mediated cell cycle arrest and ER stress response toward induction of apoptosis and be helpful for finding future cancer therapeutic targets in prostate cancer cells. -
dc.identifier.bibliographicCitation Journal of Cancer Science and Therapy, v.5, no.1, pp.023 - 030 -
dc.identifier.doi 10.4172/1948-5956.1000180 -
dc.identifier.issn 1948-5956 -
dc.identifier.scopusid 2-s2.0-84873204498 -
dc.identifier.uri https://scholarworks.unist.ac.kr/handle/201301/3295 -
dc.identifier.url https://www.omicsonline.org/gene-expression-profiling-from-a-prostate-cancer-pc-3-cell-line-treated-with-salinomycin-predicts-cell-cycle-arrest-and-endoplasmic-reticulumstress-1948-5956.1000180.php?aid=10386 -
dc.language 영어 -
dc.publisher OMICS Publishing Group -
dc.title Gene expression profiling from a prostate cancer PC-3 cell line treated with salinomycin predicts cell cycle arrest and endoplasmic reticulum stress -
dc.type Article -
dc.description.isOpenAccess FALSE -
dc.description.journalRegisteredClass scopus -
dc.subject.keywordAuthor Apoptosis -
dc.subject.keywordAuthor Cell cycle -
dc.subject.keywordAuthor Endoplasmic reticulum stress -
dc.subject.keywordAuthor Gene expression analysis -
dc.subject.keywordAuthor Proliferation -
dc.subject.keywordAuthor Prostate cancer -
dc.subject.keywordAuthor Salinomycin -

qrcode

Items in Repository are protected by copyright, with all rights reserved, unless otherwise indicated.