BROWSE

Related Researcher

Author

Kim, Byeong-Su
Soft and Hybrid Nanomaterials Lab
Research Interests
  • Carbon materials, polymer, Layer-by-Layer (LbL) assembly, hyperbranched polymer, polyglycerol (PG), bio-applications

ITEM VIEW & DOWNLOAD

Sentinel lymph node imaging by a fluorescently labeled DNA tetrahedron

Cited 3 times inthomson ciCited 1 times inthomson ci
Title
Sentinel lymph node imaging by a fluorescently labeled DNA tetrahedron
Author
Kim, Kyoung-RanLee, Yong-DeokLee, TaeminKim, Byeong-SuKim, SehoonAhn, Dae-Ro
Keywords
Cancer; Clinical application; Imaging materials; In-Vivo imaging; Lymphatic vessels; Nodal status; Retention time; Sentinel lymph nodes
Issue Date
201307
Publisher
ELSEVIER SCI LTD
Citation
BIOMATERIALS, v.34, no.21, pp.5226 - 5235
Abstract
Sentinel lymph nodes (SLNs) are the first lymph nodes which cancer cells reach after traveling through lymphatic vessels from the primary tumor. Evaluating the nodal status is crucial in accurate staging of human cancers and accordingly determines prognosis and the most appropriate treatment The commonly used methods for SLN identification in clinics are based on employment of a colloid of radionuclide or injection of a small dye. Although these methods have certainly contributed to improve surgical practice, new imaging materials are still required to overcome drawbacks of the techniques such as inconvenience of handling radioactive materials and short retention time of small dyes in SLNs. Here, we prepare a fluorescence-labeled DNA tetrahedron and perform SLN imaging by using the DNA nanoconstruct With a successful identification of SLNs by the DNA nanoconstruct, we suggest that DNA tetrahedron hold great promises for clinical applications.
URI
Go to Link
DOI
http://dx.doi.org/10.1016/j.biomaterials.2013.03.074
ISSN
0142-9612
Appears in Collections:
SNS_Journal Papers

find_unist can give you direct access to the published full text of this article. (UNISTARs only)

Show full item record

qr_code

  • mendeley

    citeulike

Items in DSpace are protected by copyright, with all rights reserved, unless otherwise indicated.

MENU