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Author

Kim, Byeong-Su
Soft and Hybrid Nanomaterials Lab
Research Interests
  • Carbon materials, polymer, Layer-by-Layer (LbL) assembly, hyperbranched polymer, polyglycerol (PG), bio-applications

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MAD (Multiagent Delivery) Nanolayer: Delivering Multiple Therapeutics from Hierarchically Assembled Surface Coatings

Cited 62 times inthomson ciCited 63 times inthomson ci
Title
MAD (Multiagent Delivery) Nanolayer: Delivering Multiple Therapeutics from Hierarchically Assembled Surface Coatings
Author
Kim, Byeong-SuSmith, Renee C.Poon, ZhiyongHammond, Paula T.
Keywords
Amino esters; Amphiphilic block copolymers; Biomacromolecules; Biomedical surfaces; Chemical characteristic; Controlled release; Dextran sulfates; Dipping method; Film processing; Human smooth muscle cells; Hydrophobic drug; In-vitro; Layer-by-layer films; Multi-Agent; Nano layers; Paclitaxel; Release kinetics; Release profiles; Small molecules; Structural component; Surface coatings; Therapeutic activity; Therapeutic agents
Issue Date
200912
Publisher
AMER CHEMICAL SOC
Citation
LANGMUIR, v.25, no.24, pp.14086 - 14092
Abstract
We present hydrolytically degradable polymeric multilayer films that call codeliver multiple therapeutics of differing chemical characteristics (charged biomacromolecules and neutral hydrophobic small molecules) from a surface. This multiagent-delivery (MAD) nanolayer system integrates the hydrolytically degradable poly(beta-amino ester) as a structural component to control the degradation of the multilayers to release active therapeutic macromolecules as well as hydrophobic drugs imbedded within amphiphilic block copolymer micellar carriers within layer-by-layer (LbL) Films, which would otherwise be difficult to include within the multilayers. By varying the anionic therapeutic agents (heparin and dextran sulfate) within the multilayer, we examine how different structural components call be used to control the release kinetics of multiple therapeutics from MAD nanolayers. Controlled release profiles and the in vitro efficacy of the MAD nanolayers ill Suppressing the growth of human smooth muscle cell lines were evaluated. The dual delivery of a charged macromolecular heparin and a small hydrophobic drug, paclitaxel, is found to be synergistic and beneficial toward effective therapeutic activity. Furthermore, we compared the classical dipping method that we employed here with an automated spray-LbL technique. Spray-LbL significantly facilitates film processing time while preserving the characteristic release profiles of the MAD nanolayers. With the highly versatile and tunable nature or LbL assembly, we anticipate that MAD nanolayers call provide a unique platform for delivering multiple therapeutics from macromolecules to small molecules with distinct release profiles for applications in biological and biomedical surface coatings.
URI
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DOI
http://dx.doi.org/10.1021/la9017618
ISSN
0743-7463
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