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Author

Oh, Joon Hak
Organic Electronics Lab
Research Interests
  • Nano Molecular Electronics, Flexible Electronics, Organic Electronic Materials

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Flexible FET-Type VEGF Aptasensor Based on Nitrogen-Doped Graphene Converted from Conducting Polymer

Cited 36 times inthomson ciCited 32 times inthomson ci
Title
Flexible FET-Type VEGF Aptasensor Based on Nitrogen-Doped Graphene Converted from Conducting Polymer
Author
Kwon, Oh SeokPark, Seon JooHong, Jin-YongHan, A-ReumLee, Jun SeopLee, James S.Oh, Joon HakJang, Jyongsik
Keywords
Anti-vascular endothelial growth factors; Aptamers; aptasensor; Cancer biomarkers; Cu substrate; Flexible process; Flexible substrate; Heteroatoms; High sensitivity; Low concentrations; N-doped; Nitrogen-doped; Post-silicon; RNA aptamer; Target molecule; Vapor deposition polymerization; Vascular endothelial growth factor
Issue Date
201202
Publisher
AMER CHEMICAL SOC
Citation
ACS NANO, v.6, no.2, pp.1486 - 1493
Abstract
Graphene-based field-effect transistors (FETs) have been developed rapidly and are currently considered as an alternative for postsilicon electronics. In this study, polypyrrole-converted nitrogen-doped few-layer graphene (PPy-NDFLG) was grown on Cu substrate by chemical vapor deposition combined with vapor deposition polymerization and then transferred onto a flexible substrate. Furthermore, antivascular endothelial growth factor (VEGF) RNA aptamer conjugated PPy-NDFLG was integrated Into a liquid-ion gated FET geometry to fabricate a high-performance VEGF aptamer-based sensor. Field-induced high sensitivity was observed for the analyte-binding events, eventually leading to the recognition of the target molecules at an unprecedentedly low concentration (100 fM). Additionally, the aptasensor had excellent reusability, mechanical bendability, and durability In the flexible process. The developed methodology describes, for the first time, the fabrication of N-doped graphene using conducting polymers including heteroatoms in their structures as the carbonization precursor and demonstrates its use in a high-performance, flexible FET-type aptasensor to detect vascular endothelial growth factor as a cancer biomarker.
URI
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DOI
http://dx.doi.org/10.1021/nn204395n
ISSN
1936-0851
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