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Min, Kyung-Tai
Molecular & Cellular Neurobiology Lab(Min Lab)
Research Interests
  • Local protein synthesis, learning & memory, behavior, mitochondrial dynamics

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DSCR1 interacts with FMRP and is required for spine morphogenesis and local protein synthesis

Cited 10 times inthomson ciCited 9 times inthomson ci
Title
DSCR1 interacts with FMRP and is required for spine morphogenesis and local protein synthesis
Author
Wang, WeiZhu, John Z.Chang, Karen T.Min, Kyung-Tai
Keywords
down syndrome; DSCR1; FMRP; Fragile X syndrome; local protein synthesis
Issue Date
201209
Publisher
NATURE PUBLISHING GROUP
Citation
EMBO JOURNAL, v.31, no.18, pp.3655 - 3666
Abstract
Most common genetic factors known to cause intellectual disability are Down syndrome and Fragile X syndrome. However, the underlying cellular and molecular mechanisms of intellectual disability remain unclear. Recently, dendritic spine dysmorphogenesis and impaired local protein synthesis are posited to contribute to the cellular mechanisms of intellectual disability. Here, we show that Down syndrome critical region1 (DSCR1) interacts with Fragile X mental retardation protein (FMRP) and regulates both dendritic spine morphogenesis and local protein synthesis. Interestingly, decreasing the level of FMRP restores the DSCR1-induced changes in dendritic spine morphology. Our results imply that DSCR1 is a novel regulator of FMRP and that Fragile X syndrome and Down syndrome may share disturbances in common pathways that regulate dendritic spine morphology and local protein synthesis.
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DOI
http://dx.doi.org/10.1038/emboj.2012.190
ISSN
0261-4189
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