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DC Field | Value | Language |
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dc.citation.number | 6 | - |
dc.citation.startPage | e00537-19 | - |
dc.citation.title | MOLECULAR AND CELLULAR BIOLOGY | - |
dc.citation.volume | 40 | - |
dc.contributor.author | Kwon, Paul Kwangho | - |
dc.contributor.author | Lee, Kyung-Ha | - |
dc.contributor.author | Kim, Ji-hyung | - |
dc.contributor.author | Tae, Sookil | - |
dc.contributor.author | Ham, Seokjin | - |
dc.contributor.author | Jeong, Young-Hun | - |
dc.contributor.author | Kim, Sung Wook | - |
dc.contributor.author | Kang, Byunghee | - |
dc.contributor.author | Kim, Hyo-Min | - |
dc.contributor.author | Choi, Jung-Hyun | - |
dc.contributor.author | Yi, Hee | - |
dc.contributor.author | Ku, Hyun-Ok | - |
dc.contributor.author | Roh, Tae-Young | - |
dc.contributor.author | Lim, Chunghun | - |
dc.contributor.author | Kim, Kyong-Tai | - |
dc.date.accessioned | 2023-12-21T18:06:57Z | - |
dc.date.available | 2023-12-21T18:06:57Z | - |
dc.date.created | 2020-03-04 | - |
dc.date.issued | 2020-02 | - |
dc.description.abstract | Circadian gene expression is defined by the gene-specific phase and amplitude of daily oscillations in mRNA and protein levels. D site-binding protein mRNA (Dbp mRNA) shows high-amplitude oscillation; however, the underlying mechanism remains elusive. Here, we demonstrate that heterogeneous nuclear ribonucleoprotein K (hnRNP K) is a key regulator that activates Dbp transcription via the poly(C) motif within its proximal promoter. Biochemical analyses identified hnRNP K as a specific protein that directly associates with the poly(C) motif in vitro. Interestingly, we further confirmed the rhythmic binding of endogenous hnRNP K within the Dbp promoter through chromatin immunoprecipitation as well as the cycling expression of hnRNP K. Finally, knockdown of hnRNP K decreased mRNA oscillation in both Dbp and Dbp-dependent clock genes. Taken together, our results show rhythmic protein expression of hnRNP K and provide new insights into its function as a transcriptional amplifier of Dbp. | - |
dc.identifier.bibliographicCitation | MOLECULAR AND CELLULAR BIOLOGY, v.40, no.6, pp.e00537-19 | - |
dc.identifier.doi | 10.1128/mcb.00537-19 | - |
dc.identifier.issn | 0270-7306 | - |
dc.identifier.scopusid | 2-s2.0-85080831832 | - |
dc.identifier.uri | https://scholarworks.unist.ac.kr/handle/201301/31563 | - |
dc.identifier.url | https://mcb.asm.org/content/40/6/e00537-19 | - |
dc.identifier.wosid | 000517840900004 | - |
dc.language | 영어 | - |
dc.publisher | American Society for Microbiology | - |
dc.title | hnRNP K Supports High-Amplitude D Site-Binding Protein mRNA (Dbp mRNA) Oscillation To Sustain Circadian Rhythms | - |
dc.type | Article | - |
dc.description.isOpenAccess | FALSE | - |
dc.type.docType | Article | - |
dc.description.journalRegisteredClass | scie | - |
dc.description.journalRegisteredClass | scopus | - |
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