Full metadata record
DC Field | Value | Language |
---|---|---|
dc.citation.number | 3 | - |
dc.citation.startPage | 773 | - |
dc.citation.title | NUTRIENTS | - |
dc.citation.volume | 12 | - |
dc.contributor.author | Lee, Jae Min | - |
dc.contributor.author | Choi, Sun Sil | - |
dc.contributor.author | Park, Mi Hyeon | - |
dc.contributor.author | Jang, Hyunduk | - |
dc.contributor.author | Lee, Yo Han | - |
dc.contributor.author | Khim, Keon Woo | - |
dc.contributor.author | Oh, Sei Ryang | - |
dc.contributor.author | Park, Jiyoung | - |
dc.contributor.author | Ryu, Hyung Won | - |
dc.contributor.author | Choi, Jang Hyun | - |
dc.date.accessioned | 2023-12-21T17:49:45Z | - |
dc.date.available | 2023-12-21T17:49:45Z | - |
dc.date.created | 2020-03-16 | - |
dc.date.issued | 2020-03 | - |
dc.description.abstract | The chronic low-grade inflammation in adipose tissue plays a causal role in obesity-induced insulin resistance and its associated pathophysiological consequences. In this study, we investigated the effects of extracts of Broussonetia papyrifera root bark (PRE) and its bioactive components on inflammation and insulin sensitivity. PRE inhibited TNF-alpha-induced NF-kappa B transcriptional activity in the NF-kappa B luciferase assay and pro-inflammatory genes' expression by blocking phosphorylation of I kappa B and NF-kappa B in 3T3-L1 adipocytes, which were mediated by activating AMPK. Ten-week-high fat diet (HFD)-fed C57BL6 male mice treated with PRE had improved glucose intolerance and decreased inflammation in adipose tissue, as indicated by reductions in NF-kappa B phosphorylation and pro-inflammatory genes' expression. Furthermore, PRE activated AMP-activated protein kinase (AMPK) and reduced lipogenic genes' expression in both adipose tissue and liver. Finally, we identified broussoflavonol B (BF) and kazinol J (KJ) as bioactive constituents to suppress pro-inflammatory responses via activating AMPK in 3T3-L1 adipocytes. Taken together, these results indicate the therapeutic potential of PRE, especially BF or KJ, in metabolic diseases such as obesity and type 2 diabetes. | - |
dc.identifier.bibliographicCitation | NUTRIENTS, v.12, no.3, pp.773 | - |
dc.identifier.doi | 10.3390/nu12030773 | - |
dc.identifier.issn | 2072-6643 | - |
dc.identifier.scopusid | 2-s2.0-85081576788 | - |
dc.identifier.uri | https://scholarworks.unist.ac.kr/handle/201301/31539 | - |
dc.identifier.url | https://www.mdpi.com/2072-6643/12/3/773 | - |
dc.identifier.wosid | 000531831000182 | - |
dc.language | 영어 | - |
dc.publisher | MDPI | - |
dc.title | Broussonetia papyrifera Root Bark Extract Exhibits Anti-inflammatory Effects on Adipose Tissue and Improves Insulin Sensitivity Potentially Via AMPK Activation | - |
dc.type | Article | - |
dc.description.isOpenAccess | TRUE | - |
dc.relation.journalWebOfScienceCategory | Nutrition & Dietetics | - |
dc.relation.journalResearchArea | Nutrition & Dietetics | - |
dc.type.docType | Article | - |
dc.description.journalRegisteredClass | scie | - |
dc.description.journalRegisteredClass | scopus | - |
dc.subject.keywordAuthor | Broussonetia papyrifera root bark | - |
dc.subject.keywordAuthor | adipocyte | - |
dc.subject.keywordAuthor | inflammation | - |
dc.subject.keywordAuthor | AMPK | - |
dc.subject.keywordAuthor | insulin sensitivity | - |
dc.subject.keywordPlus | NF-KAPPA-B | - |
dc.subject.keywordPlus | PROTEIN-KINASE | - |
dc.subject.keywordPlus | KAZINOL-B | - |
dc.subject.keywordPlus | INFLAMMATION | - |
dc.subject.keywordPlus | POLYPHENOLS | - |
dc.subject.keywordPlus | RESISTANCE | - |
dc.subject.keywordPlus | RESPONSES | - |
dc.subject.keywordPlus | LEAVES | - |
Items in Repository are protected by copyright, with all rights reserved, unless otherwise indicated.
Tel : 052-217-1404 / Email : scholarworks@unist.ac.kr
Copyright (c) 2023 by UNIST LIBRARY. All rights reserved.
ScholarWorks@UNIST was established as an OAK Project for the National Library of Korea.