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Author

Kim, Taesung
Microfluidics & Nanomechatronics Lab (μFNM)
Research Interests
  • Micro-/Nanofluidics

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Microfabricated ratchet structures for concentrating and patterning motile bacterial cells

Cited 6 times inthomson ciCited 4 times inthomson ci
Title
Microfabricated ratchet structures for concentrating and patterning motile bacterial cells
Author
Kim, Sang YubLee, Eun SeLee, Ho JaeLee, Se YeonLee, Sung KukKim, Taesung
Keywords
Bacterial cells; Circular channels; Concentration rates; Concentrator design; E. coli; Electrical energy sources; Micro-fluidic devices; Microfabricated; Motile cells; Motility studies; Spatial patterning; Stand -alone
Issue Date
201009
Publisher
IOP PUBLISHING LTD
Citation
JOURNAL OF MICROMECHANICS AND MICROENGINEERING, v.20, no.9, pp.1 - 6
Abstract
We present a novel microfabricated concentrator for Escherichia coli that can be a stand-alone and self-contained microfluidic device because it utilizes the motility of cells. First of all, we characterize the motility of E. coli cells and various ratcheting structures that can guide cells to move in a desired direction in straight and circular channels. Then, we combine these ratcheting microstructures with the intrinsic tendency of cells to swim on the right side in microchannels to enhance the concentration rates up to 180 fold until the concentrators are fully filled with cells. Furthermore, we demonstrate that cells can be positioned and concentrated with a constant spacing distance on a surface, allowing spatial patterning of motile cells. These results can be applied to biosorption or biosensor devices that are powered by motile cells because they can be highly concentrated without any external mechanical and electrical energy sources. Hence, we believe that the concentrator design holds considerable potential to be applied for concentrating and patterning other motile microbes and providing a versatile structure for motility study of bacterial cells.
URI
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DOI
http://dx.doi.org/10.1088/0960-1317/20/9/095006
ISSN
0960-1317
Appears in Collections:
MNE_Journal Papers
ECHE_Journal Papers

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