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Author

Ghim, Cheol-Min
Physical Biology & Biological Physics
Research Interests
  • Control of complex networks, stochastic cell biology, biochemical information processing, human microbiome, ecological inference

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Microbial linguistics: perspectives and applications of microbial cell-to-cell communication

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Title
Microbial linguistics: perspectives and applications of microbial cell-to-cell communication
Author
Mitchell, Robert J.Lee, Sung KukKim, TaesungGhim, Cheol-Min
Keywords
Microbial community; Microchemostat; Quorum sensing; Synthetic biology
Issue Date
201101
Publisher
KOREAN SOCIETY BIOCHEMISTRY & MOLECULAR BIOLOGY
Citation
BMB REPORTS, v.44, no.1, pp.1 - 10
Abstract
Inter-cellular communication via diffusible small molecules is a defining character not only of multicellular forms of life but also of single-celled organisms. A large number of bacterial genes are regulated by the change of chemical milieu mediated by the local population density of its own species or others. The cell density-dependent "autoinducer" molecules regulate the expression of those genes involved in genetic competence, biofilm formation and persistence, virulence, sporulation, bioluminescence, antibiotic production, and many others. Recent innovations in recombinant DNA technology and micro-/nano-fluidics systems render the genetic circuitry responsible for cell-to-cell communication feasible to and malleable via synthetic biological approaches. Here we review the current understanding of the molecular biology of bacterial intercellular communication and the novel experimental protocols and platforms used to investigate this phenomenon. A particular emphasis is given to the genetic regulatory circuits that provide the standard building blocks which constitute the syntax of the biochemical communication network Thus, this review gives focus to the engineering principles necessary for rewiring bacterial chemo-communication for various applications, ranging from population-level gene expression control to the study of host-pathogen interactions.
URI
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DOI
http://dx.doi.org/10.5483/BMBRep.2011.44.1.1
ISSN
1976-6696
Appears in Collections:
MNE_Journal Papers
SLS_Journal Papers
ECHE_Journal Papers

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