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DC Field | Value | Language |
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dc.citation.number | 5 | - |
dc.citation.startPage | e468 | - |
dc.citation.title | PLOS ONE | - |
dc.citation.volume | 2 | - |
dc.contributor.author | Savir, Yonatan | - |
dc.contributor.author | Tlusty, Tsvi | - |
dc.date.accessioned | 2023-12-22T09:14:35Z | - |
dc.date.available | 2023-12-22T09:14:35Z | - |
dc.date.created | 2020-02-20 | - |
dc.date.issued | 2007-05 | - |
dc.description.abstract | To perform recognition, molecules must locate and specifically bind their targets within a noisy biochemical environment with many look-alikes. Molecular recognition processes, especially the induced-fit mechanism, are known to involve conformational changes. This raises a basic question: Does molecular recognition gain any advantage by such conformational changes? By introducing a simple statistical-mechanics approach, we study the effect of conformation and flexibility on the quality of recognition processes. Our model relates specificity to the conformation of the participant molecules and thus suggests a possible answer: Optimal specificity is achieved when the ligand is slightly off target; that is, a conformational mismatch between the ligand and its main target improves the selectivity of the process. This indicates that deformations upon binding serve as a conformational proofreading mechanism, which may be selected for via evolution. | - |
dc.identifier.bibliographicCitation | PLOS ONE, v.2, no.5, pp.e468 | - |
dc.identifier.doi | 10.1371/journal.pone.0000468 | - |
dc.identifier.issn | 1932-6203 | - |
dc.identifier.scopusid | 2-s2.0-55849099561 | - |
dc.identifier.uri | https://scholarworks.unist.ac.kr/handle/201301/31202 | - |
dc.identifier.url | https://journals.plos.org/plosone/article?id=10.1371/journal.pone.0000468 | - |
dc.identifier.wosid | 000207446000016 | - |
dc.language | 영어 | - |
dc.publisher | PUBLIC LIBRARY SCIENCE | - |
dc.title | Conformational Proofreading: The Impact of Conformational Changes on the Specificity of Molecular Recognition | - |
dc.type | Article | - |
dc.description.isOpenAccess | FALSE | - |
dc.relation.journalWebOfScienceCategory | Multidisciplinary Sciences | - |
dc.relation.journalResearchArea | Science & Technology - Other Topics | - |
dc.type.docType | Article | - |
dc.description.journalRegisteredClass | scie | - |
dc.description.journalRegisteredClass | scopus | - |
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