There are no files associated with this item.
Full metadata record
DC Field | Value | Language |
---|---|---|
dc.citation.endPage | 1381 | - |
dc.citation.number | 5 | - |
dc.citation.startPage | 1369 | - |
dc.citation.title | JOURNAL OF MAGNETIC RESONANCE IMAGING | - |
dc.citation.volume | 51 | - |
dc.contributor.author | Jin, Seokha | - |
dc.contributor.author | Han, SoHyun | - |
dc.contributor.author | Stoyanova, Radka | - |
dc.contributor.author | Ackerstaff, Ellen | - |
dc.contributor.author | Cho, HyungJoon | - |
dc.date.accessioned | 2023-12-21T17:39:49Z | - |
dc.date.available | 2023-12-21T17:39:49Z | - |
dc.date.created | 2019-11-18 | - |
dc.date.issued | 2020-05 | - |
dc.description.abstract | Background The manual segmentation of intact blood-brain barrier (BBB) regions in the stroke brain is cumbersome, due to the coexistence of infarction, large blood vessels, ventricles, and intact BBB regions, specifically in areas with weak signal enhancement following contrast agent injection. Hypothesis That from dynamic susceptibility contrast (DSC)-MRI alone, without user intervention, regions of weak BBB damage can be segmented based on the leakage-related parameter K-2 and the extent of intact BBB regions, needed to estimate K-2 values, determined. Study Type Feasibility. Animal Model Ten female Sprague-Dawley rats (SD, 200-250g) underwent 1-hour middle carotid artery occlusion (MCAO) and 1-day reperfusion. Two SD rats underwent 1-hour MCAO with 3-day and 5-day reperfusion. Field Strength/Sequence 7T; ADC and T-1 maps using diffusion-weighted echo planar imaging (EPI) and relaxation enhancement (RARE) with variable repetition time (TR), respectively. dynamic contrast-enhanced (DCE)-MRI using FLASH. DSC-MRI using gradient-echo EPI. Assessment Constrained nonnegative matrix factorization (cNMF) was applied to the dynamic Delta R2*-curves of DSC-MRI (<4 min) in a BBB-disrupted rat model. Areas of voxels with intact BBB, classified by automated cNMF analyses, were then used in estimating K-1 and K-2 values, and compared with corresponding values from manually-derived areas. Statistical Tests Mean +/- standard deviation of Delta T-1-differences between ischemic and healthy areas were displayed with unpaired Student's t-tests. Scatterplots were displayed with slopes and intercepts and Pearson's r values were evaluated between K-2 maps obtained with automatic (cNMF)- and manually-derived regions of interest (ROIs) of the intact BBB region. Results Mildly BBB-damaged areas (indistinguishable from DCE-MRI (10 min) parameters) were automatically segmented. Areas of voxels with intact BBB, classified by automated cNMF, matched closely the corresponding, manually-derived areas when respective areas were used in estimating K-2 maps (Pearson's r = 0.97, 12 slices). Data Conclusion Automatic segmentation of short DSC-MRI data alone successfully identified areas with intact and compromised BBB in the stroke brain and compared favorably with manual segmentation. Technical Efficacy: Stage 1 J. Magn. Reson. Imaging 2019. | - |
dc.identifier.bibliographicCitation | JOURNAL OF MAGNETIC RESONANCE IMAGING, v.51, no.5, pp.1369 - 1381 | - |
dc.identifier.doi | 10.1002/jmri.26949 | - |
dc.identifier.issn | 1053-1807 | - |
dc.identifier.scopusid | 2-s2.0-85074571544 | - |
dc.identifier.uri | https://scholarworks.unist.ac.kr/handle/201301/31123 | - |
dc.identifier.url | https://onlinelibrary.wiley.com/doi/full/10.1002/jmri.26949 | - |
dc.identifier.wosid | 000492523400001 | - |
dc.language | 영어 | - |
dc.publisher | John Wiley & Sons Inc. | - |
dc.title | Pattern recognition analysis of dynamic susceptibility contrast (DSC)-MRI curves automatically segments tissue areas with intact blood-brain barrier in a rat stroke model: A feasibility and comparison study | - |
dc.type | Article | - |
dc.description.isOpenAccess | FALSE | - |
dc.relation.journalWebOfScienceCategory | Radiology, Nuclear Medicine & Medical Imaging | - |
dc.relation.journalResearchArea | Radiology, Nuclear Medicine & Medical Imaging | - |
dc.type.docType | Article; Early Access | - |
dc.description.journalRegisteredClass | scie | - |
dc.description.journalRegisteredClass | scopus | - |
dc.subject.keywordAuthor | pattern-recognition | - |
dc.subject.keywordAuthor | stroke model | - |
dc.subject.keywordAuthor | BBB damage | - |
dc.subject.keywordAuthor | DSC-MRI | - |
dc.subject.keywordPlus | VASCULAR-PERMEABILITY | - |
dc.subject.keywordPlus | DCE-MRI | - |
dc.subject.keywordPlus | VOLUME | - |
dc.subject.keywordPlus | FLOW | - |
dc.subject.keywordPlus | T-1 | - |
dc.subject.keywordPlus | GLIOMA | - |
dc.subject.keywordPlus | MAPS | - |
dc.subject.keywordPlus | FOCAL CEREBRAL-ISCHEMIA | - |
dc.subject.keywordPlus | TURBO-SPIN-ECHO | - |
dc.subject.keywordPlus | ENHANCED MRI | - |
Items in Repository are protected by copyright, with all rights reserved, unless otherwise indicated.
Tel : 052-217-1404 / Email : scholarworks@unist.ac.kr
Copyright (c) 2023 by UNIST LIBRARY. All rights reserved.
ScholarWorks@UNIST was established as an OAK Project for the National Library of Korea.