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Author

Takayama, Shuichi
Cell and Microfluidics Lab
Research Interests
  • Bio-MEMS and Microfluidics

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Constant Flow-Driven Microfluidic Oscillator for Different Duty Cycles

Cited 9 times inthomson ciCited 8 times inthomson ci
Title
Constant Flow-Driven Microfluidic Oscillator for Different Duty Cycles
Author
Kim, Sung-JinYokokawa, RyujiLesher-Perez, Sasha CaiTakayama, Shuichi
Keywords
Cell-based; Constant flow; Duty cycles; External actuators; Living cell; Micro-fluidic devices; Oscillation periods; Oscillatory flows; Rational design; Syringe pumps; Theoretical values; Wave forms
Issue Date
201201
Publisher
AMER CHEMICAL SOC
Citation
ANALYTICAL CHEMISTRY, v.84, no.2, pp.1152 - 1156
Abstract
This paper presents microfluidic devices that autonomously convert two constant flow inputs into an alternating oscillatory flow output. We accomplish this hardware embedded self-control programming using normally closed membrane valves that have an inlet, an outlet, and a membrane-pressurization chamber connected to a third terminal. Adjustment of threshold opening pressures in these 3-terminal flow switching valves enabled adjustment of oscillation periods to between 57 and 360 s with duty cycles of 0.2-0.5. These values are in relatively good agreement with theoretical values, providing the way for rational design of an even wider range of different waveform oscillations. We also demonstrate the ability to use these oscillators to perform temporally patterned delivery of chemicals to living cells. The device only needs a syringe pump, thus removing the use of complex, expensive external actuators. These tunable waveform microfluidic oscillators are envisioned to facilitate cell-based studies that require temporal stimulation
URI
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DOI
http://dx.doi.org/10.1021/ac202866b
ISSN
0003-2700
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