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DC Field | Value | Language |
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dc.citation.endPage | 15985 | - |
dc.citation.number | 45 | - |
dc.citation.startPage | 15980 | - |
dc.citation.title | PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA | - |
dc.citation.volume | 101 | - |
dc.contributor.author | Myung, K | - |
dc.contributor.author | Smith, S | - |
dc.contributor.author | Kolodner, RD | - |
dc.date.accessioned | 2023-12-22T10:41:08Z | - |
dc.date.available | 2023-12-22T10:41:08Z | - |
dc.date.created | 2020-01-31 | - |
dc.date.issued | 2004-11 | - |
dc.description.abstract | The accumulation of gross chromosomal rearrangements (GCRs) is characteristic of cancer cells. Multiple pathways that prevent GCRs, including S-phase cell cycle checkpoints, homologous recombination, telomere maintenance, suppression of de novo telomere addition, chromatin assembly, and mismatch repair, have been identified in Saccharomyces cerevisiae. However, pathways that promote the formation of GCRs are not as well understood. Of these, the de novo telomere addition pathway and nonhomologous end-joining are the best characterized. Here, we demonstrate that defects in the mitotic checkpoint and the mitotic exit network can suppress GCRs in strains containing defects that increase the GCR rate. These data suggest that functional mitotic checkpoints can play a role in the formation of genome rearrangements. | - |
dc.identifier.bibliographicCitation | PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA, v.101, no.45, pp.15980 - 15985 | - |
dc.identifier.doi | 10.1073/pnas.0407010101 | - |
dc.identifier.issn | 0027-8424 | - |
dc.identifier.scopusid | 2-s2.0-8644251877 | - |
dc.identifier.uri | https://scholarworks.unist.ac.kr/handle/201301/31085 | - |
dc.identifier.url | https://www.pnas.org/content/101/45/15980 | - |
dc.identifier.wosid | 000225196800031 | - |
dc.language | 영어 | - |
dc.publisher | NATL ACAD SCIENCES | - |
dc.title | Mitotic checkpoint function in the formation of gross chromosomal rearrangements in Saccharomyces cerevisiae | - |
dc.type | Article | - |
dc.description.isOpenAccess | FALSE | - |
dc.relation.journalWebOfScienceCategory | Multidisciplinary Sciences | - |
dc.relation.journalResearchArea | Science & Technology - Other Topics | - |
dc.type.docType | Article | - |
dc.description.journalRegisteredClass | scie | - |
dc.description.journalRegisteredClass | scopus | - |
dc.subject.keywordAuthor | genome instability | - |
dc.subject.keywordAuthor | mutation | - |
dc.subject.keywordAuthor | spindle | - |
dc.subject.keywordAuthor | DNA damage | - |
dc.subject.keywordPlus | STRAND BREAK REPAIR | - |
dc.subject.keywordPlus | DNA MISMATCH REPAIR | - |
dc.subject.keywordPlus | BUDDING YEAST | - |
dc.subject.keywordPlus | SPINDLE CHECKPOINT | - |
dc.subject.keywordPlus | S-PHASE | - |
dc.subject.keywordPlus | GENOMIC INSTABILITY | - |
dc.subject.keywordPlus | TELOMERE ELONGATION | - |
dc.subject.keywordPlus | DAMAGE RESPONSE | - |
dc.subject.keywordPlus | SYNDROME GENE | - |
dc.subject.keywordPlus | HUMAN CANCERS | - |
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