There are no files associated with this item.
Full metadata record
DC Field | Value | Language |
---|---|---|
dc.citation.endPage | 708 | - |
dc.citation.number | 5 | - |
dc.citation.startPage | 703 | - |
dc.citation.title | JOURNAL OF CELL BIOLOGY | - |
dc.citation.volume | 175 | - |
dc.contributor.author | Motegi, Akira | - |
dc.contributor.author | Sood, Raman | - |
dc.contributor.author | Moinova, Helen | - |
dc.contributor.author | Markowitz, Sanford D. | - |
dc.contributor.author | Liu, Pu Paul | - |
dc.contributor.author | Myung, Kyungjae | - |
dc.date.accessioned | 2023-12-22T09:38:51Z | - |
dc.date.available | 2023-12-22T09:38:51Z | - |
dc.date.created | 2020-01-31 | - |
dc.date.issued | 2006-12 | - |
dc.description.abstract | Differential modi. cations of proliferating cell nuclear antigen ( PCNA) determine DNA repair pathways at stalled replication forks. In yeast, PCNA monoubiquitination by the ubiquitin ligase (E3) yRad18 promotes translesion synthesis (TLS), whereas the lysine63 - linked polyubiquitination of PCNA by yRad5 (E3) promotes the error-free mode of bypass. The yRad5-dependent pathway is important to prevent genomic instability during replication, although its exact molecular mechanism is poorly understood. This mechanism has remained totally elusive in mammals because of the lack of apparent RAD5 homologues. We report that a putative tumor suppressor gene, SHPRH, is a human orthologue of yeast RAD5. SHPRH associates with PCNA, RAD18, and the ubiquitin-conjugating enzyme UBC13 (E2) and promotes methyl methanesulfonate (MMS)-induced PCNA polyubiquitination. The reduction of SHPRH by stable short hairpin RNA increases sensitivity to MMS and enhances genomic instability. Therefore, the yRad5/SHPRH-dependent pathway is a conserved and fundamental DNA repair mechanism that protects the genome from genotoxic stress. | - |
dc.identifier.bibliographicCitation | JOURNAL OF CELL BIOLOGY, v.175, no.5, pp.703 - 708 | - |
dc.identifier.doi | 10.1083/jcb.200606145 | - |
dc.identifier.issn | 0021-9525 | - |
dc.identifier.scopusid | 2-s2.0-33845310025 | - |
dc.identifier.uri | https://scholarworks.unist.ac.kr/handle/201301/31066 | - |
dc.identifier.url | https://rupress.org/jcb/article/175/5/703/44608/Human-SHPRH-suppresses-genomic-instability-through | - |
dc.identifier.wosid | 000242770000004 | - |
dc.language | 영어 | - |
dc.publisher | ROCKEFELLER UNIV PRESS | - |
dc.title | Human SHPRH suppresses genomic instability through proliferating cell nuclear antigen polyubiquitination | - |
dc.type | Article | - |
dc.description.isOpenAccess | FALSE | - |
dc.relation.journalWebOfScienceCategory | Cell Biology | - |
dc.relation.journalResearchArea | Cell Biology | - |
dc.type.docType | Article | - |
dc.description.journalRegisteredClass | scie | - |
dc.description.journalRegisteredClass | scopus | - |
dc.subject.keywordPlus | GROSS CHROMOSOMAL REARRANGEMENTS | - |
dc.subject.keywordPlus | DEFECTIVE POSTREPLICATION REPAIR | - |
dc.subject.keywordPlus | DNA-POLYMERASE-ETA | - |
dc.subject.keywordPlus | SACCHAROMYCES-CEREVISIAE | - |
dc.subject.keywordPlus | MONOUBIQUITINATED PCNA | - |
dc.subject.keywordPlus | XERODERMA-PIGMENTOSUM | - |
dc.subject.keywordPlus | DAMAGE BYPASS | - |
dc.subject.keywordPlus | UBIQUITIN | - |
dc.subject.keywordPlus | RAD6 | - |
dc.subject.keywordPlus | SUMO | - |
Items in Repository are protected by copyright, with all rights reserved, unless otherwise indicated.
Tel : 052-217-1404 / Email : scholarworks@unist.ac.kr
Copyright (c) 2023 by UNIST LIBRARY. All rights reserved.
ScholarWorks@UNIST was established as an OAK Project for the National Library of Korea.