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DC Field | Value | Language |
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dc.citation.endPage | 1093 | - |
dc.citation.number | 7 | - |
dc.citation.startPage | 1083 | - |
dc.citation.title | JOURNAL OF CELL BIOLOGY | - |
dc.citation.volume | 181 | - |
dc.contributor.author | Banerjee, Soma | - |
dc.contributor.author | Smith, Stephanie | - |
dc.contributor.author | Oum, Ji-Hyun | - |
dc.contributor.author | Liaw, Hung-Jiun | - |
dc.contributor.author | Hwang, Ji-Young | - |
dc.contributor.author | Sikdar, Nilabja | - |
dc.contributor.author | Motegi, Akira | - |
dc.contributor.author | Lee, Sang Eun | - |
dc.contributor.author | Myung, Kyungjae | - |
dc.date.accessioned | 2023-12-22T08:38:55Z | - |
dc.date.available | 2023-12-22T08:38:55Z | - |
dc.date.created | 2020-01-31 | - |
dc.date.issued | 2008-06 | - |
dc.description.abstract | ross chromosomal rearrangement (GCR) is a type of genomic instability associated with many cancers. In yeast, multiple pathways cooperate to suppress GCR. In a screen for genes that promote GCR, we identified MPH1, which encodes a 3'-5' DNA helicase. Overexpression of Mph1p in yeast results in decreased efficiency of homologous recombination (HR) as well as delayed Rad51p recruitment to double-strand breaks (DSBs), which suggests that Mph1p promotes GCR by partially suppressing HR. A function for Mph1p in suppression of HR is further supported by the observation that deletion of both mph1 and srs2 synergistically sensitize cells to methyl methanesulfonate-induced DNA damage. The GCR-promoting activity of Mph1p appears to depend on its interaction with replication protein A (RPA). Consistent with this observation, excess Mph1p stabilizes RPA at DSBs. Furthermore, spontaneous RPA foci at DSBs are destabilized by the mph 1 Delta mutation. Therefore, Mph1p promotes GCR formation by partially suppressing HR, likely through its interaction with RPA. | - |
dc.identifier.bibliographicCitation | JOURNAL OF CELL BIOLOGY, v.181, no.7, pp.1083 - 1093 | - |
dc.identifier.doi | 10.1083/jcb.200711146 | - |
dc.identifier.issn | 0021-9525 | - |
dc.identifier.scopusid | 2-s2.0-46249091062 | - |
dc.identifier.uri | https://scholarworks.unist.ac.kr/handle/201301/31060 | - |
dc.identifier.url | https://rupress.org/jcb/article/181/7/1083/45281/Mph1p-promotes-gross-chromosomal-rearrangement | - |
dc.identifier.wosid | 000257547200006 | - |
dc.language | 영어 | - |
dc.publisher | ROCKEFELLER UNIV PRESS | - |
dc.title | Mph1p promotes gross chromosomal rearrangement through partial inhibition of homologous recombination | - |
dc.type | Article | - |
dc.description.isOpenAccess | FALSE | - |
dc.relation.journalWebOfScienceCategory | Cell Biology | - |
dc.relation.journalResearchArea | Cell Biology | - |
dc.type.docType | Article | - |
dc.description.journalRegisteredClass | scie | - |
dc.description.journalRegisteredClass | scopus | - |
dc.subject.keywordPlus | SACCHAROMYCES-CEREVISIAE HOMOLOG | - |
dc.subject.keywordPlus | DNA-DAMAGE | - |
dc.subject.keywordPlus | GENOMIC INSTABILITY | - |
dc.subject.keywordPlus | HELICASE | - |
dc.subject.keywordPlus | REPLICATION | - |
dc.subject.keywordPlus | REPAIR | - |
dc.subject.keywordPlus | GENE | - |
dc.subject.keywordPlus | SUPPRESSION | - |
dc.subject.keywordPlus | PROTEIN | - |
dc.subject.keywordPlus | HEF | - |
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