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DC Field | Value | Language |
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dc.citation.endPage | 211 | - |
dc.citation.number | 2 | - |
dc.citation.startPage | 201 | - |
dc.citation.title | ONCOGENE | - |
dc.citation.volume | 30 | - |
dc.contributor.author | Park, H. D. | - |
dc.contributor.author | Lee, Y. | - |
dc.contributor.author | Oh, Y. K. | - |
dc.contributor.author | Jung, J. G. | - |
dc.contributor.author | Park, Y. W. | - |
dc.contributor.author | Myung, K. | - |
dc.contributor.author | Kim, K-H | - |
dc.contributor.author | Koh, S. S. | - |
dc.contributor.author | Lim, D-S | - |
dc.date.accessioned | 2023-12-22T06:36:51Z | - |
dc.date.available | 2023-12-22T06:36:51Z | - |
dc.date.created | 2020-01-31 | - |
dc.date.issued | 2011-01 | - |
dc.description.abstract | Pancreatic adenocarcinoma upregulated factor (PAUF) is overproduced in certain types of cancer. However, little is known of the tumorigenic function of PAUF. In this study, we report the X-ray crystal structure of PAUF and reveal that PAUF is a mammalian lectin normally found in plant lectins. We also identify PAUF as an endogenous ligand of Toll-like receptor 2 (TLR2) and TLR4 by screening extracellular domain receptor pools. We further confirmed the specificity of the PAUF-TLR2 interaction. PAUF induces extracellular signal-regulated kinase (ERK) phosphorylation and activates the IKK-beta-mediated TPL2/MEK/ERK signaling pathway through TLR2. In agreement with the result of TLR2-mediated ERK activation by PAUF, PAUF induces increased expression of the protumorigenic cytokines RANTES and MIF in THP-1 cells. However, PAUF does not fully activate I kappa-B-alpha signaling pathways in THP-1 cells, and fails to translocate the p65 subunit of the nuclear factor-kappa B (NF-kappa B) complex into the nucleus, resulting in no NF-kappa B activation. Surprisingly, we found that PAUF also associated with the CXC chemokine receptor (CXCR4)-TLR2 complex and inhibited CXCR4-dependent, TLR2-mediated NF-kappa B activation. Together, these findings suggest that the new cancer-associated ligand, PAUF, may activate TLR-mediated ERK signaling to produce the protumorigenic cytokines, but inhibits TLR-mediated NF-kappa B signaling, thereby facilitating tumor growth and escape from innate immune surveillance. | - |
dc.identifier.bibliographicCitation | ONCOGENE, v.30, no.2, pp.201 - 211 | - |
dc.identifier.doi | 10.1038/onc.2010.401 | - |
dc.identifier.issn | 0950-9232 | - |
dc.identifier.scopusid | 2-s2.0-78651407343 | - |
dc.identifier.uri | https://scholarworks.unist.ac.kr/handle/201301/31048 | - |
dc.identifier.url | https://www.nature.com/articles/onc2010401 | - |
dc.identifier.wosid | 000286438900008 | - |
dc.language | 영어 | - |
dc.publisher | NATURE PUBLISHING GROUP | - |
dc.title | Pancreatic adenocarcinoma upregulated factor promotes metastasis by regulating TLR/CXCR4 activation | - |
dc.type | Article | - |
dc.description.isOpenAccess | FALSE | - |
dc.relation.journalWebOfScienceCategory | Biochemistry & Molecular Biology; Oncology; Cell Biology; Genetics & Heredity | - |
dc.relation.journalResearchArea | Biochemistry & Molecular Biology; Oncology; Cell Biology; Genetics & Heredity | - |
dc.type.docType | Article | - |
dc.description.journalRegisteredClass | scie | - |
dc.description.journalRegisteredClass | scopus | - |
dc.subject.keywordAuthor | PAUF | - |
dc.subject.keywordAuthor | TLR | - |
dc.subject.keywordAuthor | CXCR4 | - |
dc.subject.keywordAuthor | TPL2 | - |
dc.subject.keywordAuthor | ERK | - |
dc.subject.keywordAuthor | NF-kappa B | - |
dc.subject.keywordPlus | TOLL-LIKE RECEPTORS | - |
dc.subject.keywordPlus | TUMOR-GROWTH | - |
dc.subject.keywordPlus | CARBOHYDRATE SPECIFICITIES | - |
dc.subject.keywordPlus | STRUCTURAL BASIS | - |
dc.subject.keywordPlus | BINDING LECTINS | - |
dc.subject.keywordPlus | CANCER-CELLS | - |
dc.subject.keywordPlus | ANGIOGENESIS | - |
dc.subject.keywordPlus | LIPOPOLYSACCHARIDE | - |
dc.subject.keywordPlus | INFLAMMATION | - |
dc.subject.keywordPlus | PROGRESSION | - |
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