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DC Field | Value | Language |
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dc.citation.endPage | 368 | - |
dc.citation.number | 3 | - |
dc.citation.startPage | 357 | - |
dc.citation.title | CELL | - |
dc.citation.volume | 120 | - |
dc.contributor.author | Schumacher, B | - |
dc.contributor.author | Hanazawa, M | - |
dc.contributor.author | Lee, MH | - |
dc.contributor.author | Nayak, S | - |
dc.contributor.author | Volkmann, K | - |
dc.contributor.author | Hofmann, R | - |
dc.contributor.author | Hengartner, M | - |
dc.contributor.author | Schedl, T | - |
dc.contributor.author | Gartner, A | - |
dc.date.accessioned | 2023-12-22T10:38:09Z | - |
dc.date.available | 2023-12-22T10:38:09Z | - |
dc.date.created | 2020-01-30 | - |
dc.date.issued | 2005-02 | - |
dc.description.abstract | p53 is a tumor suppressor gene whose regulation is crucial to maintaining genome stability and for the apoptotic elimination of abnormal, potentially cancer-predisposing cells. C. elegans contains a primordial p53 gene, cep-1, that acts as a transcription factor necessary for DNA damage-induced apoptosis. In a genetic screen for negative regulators of CEP-1, we identified a mutation in GLD-1, a translational repressor implicated in multiple C. elegans germ cell fate decisions and related to mammalian Quaking proteins. CEP-1-dependent transcription of proapoptotic genes is upregulated in the gld-1(op236) mutant and an elevation of p53-mediated germ cell apoptosis in response to DNA damage is observed. Further, we demonstrate that GLD-1 mediates its repressive effect by directly binding to the 3'UTR of cep-1/p53 mRNA and repressing its translation. This study reveals that the regulation of cep-1/p53 translation influences DNA damage-induced apoptosis and demonstrates the physiological importance of this mechanism. | - |
dc.identifier.bibliographicCitation | CELL, v.120, no.3, pp.357 - 368 | - |
dc.identifier.doi | 10.1016/j.cell.2004.12.009 | - |
dc.identifier.issn | 0092-8674 | - |
dc.identifier.scopusid | 2-s2.0-13544267521 | - |
dc.identifier.uri | https://scholarworks.unist.ac.kr/handle/201301/31017 | - |
dc.identifier.url | https://www.sciencedirect.com/science/article/pii/S0092867404011705?via%3Dihub | - |
dc.identifier.wosid | 000227028900011 | - |
dc.language | 영어 | - |
dc.publisher | CELL PRESS | - |
dc.title | Translational repression of C-elegans p53 by GLD-1 regulates DNA damage-induced apoptosis | - |
dc.type | Article | - |
dc.description.isOpenAccess | FALSE | - |
dc.relation.journalWebOfScienceCategory | Biochemistry & Molecular Biology; Cell Biology | - |
dc.relation.journalResearchArea | Biochemistry & Molecular Biology; Cell Biology | - |
dc.type.docType | Article | - |
dc.description.journalRegisteredClass | scie | - |
dc.description.journalRegisteredClass | scopus | - |
dc.subject.keywordPlus | PROGRAMMED CELL-DEATH | - |
dc.subject.keywordPlus | MESSENGER-RNA TARGETS | - |
dc.subject.keywordPlus | TUMOR-SUPPRESSOR GENE | - |
dc.subject.keywordPlus | DOMAIN PROTEIN GLD-1 | - |
dc.subject.keywordPlus | CAENORHABDITIS-ELEGANS | - |
dc.subject.keywordPlus | MEIOTIC RECOMBINATION | - |
dc.subject.keywordPlus | BINDING PROTEIN | - |
dc.subject.keywordPlus | CANCER-THERAPY | - |
dc.subject.keywordPlus | QUAKING LOCUS | - |
dc.subject.keywordPlus | T-REGION | - |
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