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DC Field | Value | Language |
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dc.citation.number | 41 | - |
dc.citation.startPage | eaay0555 | - |
dc.citation.title | SCIENCE IMMUNOLOGY | - |
dc.citation.volume | 4 | - |
dc.contributor.author | Kim, Chang Gon | - |
dc.contributor.author | Jang, Mi | - |
dc.contributor.author | Kim, Youngun | - |
dc.contributor.author | Leem, Galam | - |
dc.contributor.author | Kim, Kyung Hwan | - |
dc.contributor.author | Lee, Hoyoung | - |
dc.contributor.author | Kim, Tae-Shin | - |
dc.contributor.author | Choi, Seong Jin | - |
dc.contributor.author | Kim, Hyung-Don | - |
dc.contributor.author | Han, Ji Won | - |
dc.contributor.author | Kwon, Minsuk | - |
dc.contributor.author | Kim, Jong Hoon | - |
dc.contributor.author | Lee, Andrew J. | - |
dc.contributor.author | Nam, Su Kyung | - |
dc.contributor.author | Bae, Seok-Joo | - |
dc.contributor.author | Lee, Sat Byol | - |
dc.contributor.author | Shin, Sang Joon | - |
dc.contributor.author | Park, Sung Ho | - |
dc.contributor.author | Ahn, Joong Bae | - |
dc.contributor.author | Jung, Inkyung | - |
dc.contributor.author | Lee, Kang Young | - |
dc.contributor.author | Park, Su Hyung | - |
dc.contributor.author | Kim, Hoguen | - |
dc.contributor.author | Min, Byung Soh | - |
dc.contributor.author | Shin, Eui-Cheol | - |
dc.date.accessioned | 2023-12-21T18:19:43Z | - |
dc.date.available | 2023-12-21T18:19:43Z | - |
dc.date.created | 2020-01-29 | - |
dc.date.issued | 2019-11 | - |
dc.description.abstract | Although immune checkpoint blockade therapies have demonstrated clinical efficacy in cancer treatment, harnessing this strategy is largely encumbered by resistance in multiple cancer settings. Here, we show that tumor-infiltrating T cells are severely exhausted in the microsatellite stable (MSS) colorectal cancer (CRC), a representative example of PD-1 blockade-resistant tumors. In MSS CRC, we found wound healing signature to be up-regulated and that T cell exhaustion is driven by vascular endothelial growth factor-A (VEGF-A). We report that VEGF-A induces the expression of transcription factor TOX in T cells to drive exhaustion-specific transcription program in T cells. Using a combination of in vitro, ex vivo, and in vivo mouse studies, we demonstrate that combined blockade of PD-1 and VEGF-A restores the antitumor functions of T cells, resulting in better control of MSS CRC tumors. | - |
dc.identifier.bibliographicCitation | SCIENCE IMMUNOLOGY, v.4, no.41, pp.eaay0555 | - |
dc.identifier.doi | 10.1126/sciimmunol.aay0555 | - |
dc.identifier.issn | 2470-9468 | - |
dc.identifier.scopusid | 2-s2.0-85074742367 | - |
dc.identifier.uri | https://scholarworks.unist.ac.kr/handle/201301/30960 | - |
dc.identifier.url | https://immunology.sciencemag.org/content/4/41/eaay0555 | - |
dc.identifier.wosid | 000516638800007 | - |
dc.language | 영어 | - |
dc.publisher | American Association for the Advancement of Science | - |
dc.title | VEGF-A drives TOX-dependent T cell exhaustion in anti-PD-1-resistant microsatellite stable colorectal cancers | - |
dc.type | Article | - |
dc.description.isOpenAccess | FALSE | - |
dc.relation.journalWebOfScienceCategory | Immunology | - |
dc.relation.journalResearchArea | Immunology | - |
dc.type.docType | Article | - |
dc.description.journalRegisteredClass | scie | - |
dc.description.journalRegisteredClass | scopus | - |
dc.subject.keywordPlus | IMMUNE-CHECKPOINT BLOCKADE | - |
dc.subject.keywordPlus | ENDOTHELIAL GROWTH-FACTOR | - |
dc.subject.keywordPlus | INHIBITORY RECEPTOR PD-1 | - |
dc.subject.keywordPlus | ANTI-PD-1 ANTIBODY | - |
dc.subject.keywordPlus | SOLID TUMORS | - |
dc.subject.keywordPlus | OPEN-LABEL | - |
dc.subject.keywordPlus | PHASE-I | - |
dc.subject.keywordPlus | EXPRESSION | - |
dc.subject.keywordPlus | NIVOLUMAB | - |
dc.subject.keywordPlus | RESISTANCE | - |
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