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DC Field | Value | Language |
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dc.citation.endPage | 1727 | - |
dc.citation.number | 21 | - |
dc.citation.startPage | 1722 | - |
dc.citation.title | CURRENT BIOLOGY | - |
dc.citation.volume | 11 | - |
dc.contributor.author | Schumacher, B | - |
dc.contributor.author | Hofmann, K | - |
dc.contributor.author | Boulton, S | - |
dc.contributor.author | Gartner, A | - |
dc.date.accessioned | 2023-12-22T11:41:47Z | - |
dc.date.available | 2023-12-22T11:41:47Z | - |
dc.date.created | 2020-01-30 | - |
dc.date.issued | 2001-10 | - |
dc.description.abstract | In mammals, one of the key regulators necessary for responding to genotoxic stress is the p53 transcription factor. p53 is the single most commonly mutated tumor suppressor gene in human cancers [1]. Here we report the identification of a C. elegans homolog of mammalian p53. Using RNAi and DNA cosuppression technology, we show that C. elegans p53 (cep-1) is required for DNA damage-induced apoptosis in the C. elegans germline. However, cep-1 RNAi does not affect programmed cell death occurring during worm development and physiological (radiation-independent) germ cell death. The DNA binding domain of CEP-1 is related to vertebrate p53 members and possesses the conserved residues most frequently mutated in human tumors. Consistent with this, CEP-1 acts as a transcription factor and is able to activate a transcriptional reporter containing consensus human p53 binding sites. Our data support the notion that p53-mediated transcriptional regulation is part of an ancestral pathway mediating DNA damage-induced apoptosis and reveals C. elegans as a genetically tractable model organism for studying the p53 apoptotic pathway. | - |
dc.identifier.bibliographicCitation | CURRENT BIOLOGY, v.11, no.21, pp.1722 - 1727 | - |
dc.identifier.doi | 10.1016/S0960-9822(01)00534-6 | - |
dc.identifier.issn | 0960-9822 | - |
dc.identifier.scopusid | 2-s2.0-0035975986 | - |
dc.identifier.uri | https://scholarworks.unist.ac.kr/handle/201301/30923 | - |
dc.identifier.url | https://www.sciencedirect.com/science/article/pii/S0960982201005346?via%3Dihub | - |
dc.identifier.wosid | 000172060800027 | - |
dc.language | 영어 | - |
dc.publisher | CELL PRESS | - |
dc.title | The C. elegans homolog of the p53 tumor suppressor is required for DNA damage-induced apoptosis | - |
dc.type | Article | - |
dc.description.isOpenAccess | FALSE | - |
dc.relation.journalWebOfScienceCategory | Biochemistry & Molecular Biology; Biology; Cell Biology | - |
dc.relation.journalResearchArea | Biochemistry & Molecular Biology; Life Sciences & Biomedicine - Other Topics; Cell Biology | - |
dc.type.docType | Article | - |
dc.description.journalRegisteredClass | scie | - |
dc.description.journalRegisteredClass | scopus | - |
dc.subject.keywordPlus | GENETIC-CONTROL | - |
dc.subject.keywordPlus | DROSOPHILA P53 | - |
dc.subject.keywordPlus | MUTATIONS | - |
dc.subject.keywordPlus | PROTEIN | - |
dc.subject.keywordPlus | PROGRAMMED CELL-DEATH | - |
dc.subject.keywordPlus | FUNCTIONAL GENOMIC ANALYSIS | - |
dc.subject.keywordPlus | CAENORHABDITIS-ELEGANS | - |
dc.subject.keywordPlus | INDUCED PHOSPHORYLATION | - |
dc.subject.keywordPlus | RNA INTERFERENCE | - |
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